Cochrane · systematic review · CD013518
Combination fixed‐dose beta agonist and steroid inhaler as required for adults or children with mild asthma
Crossingham, I, Turner, S, Ramakrishnan, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 33.3%Moderate 6 · 50%High 2 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
As‐required FABA/ICS inhalers compared to as‐required FABA inhalers for mild asthma
Population: mild asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Asthma exacerbation requiring systemic steroid As‐required FABA/ICS inhalers vs as‐required FABA inhalers | OR 0.45 | 2 studies · 2997 participants | High |
Hospital admission, ED and urgent care visits As‐required FABA/ICS inhalers vs as‐required FABA inhalers | OR 0.35 | 2 studies · 2997 participants | Low Downgraded: imprecision |
Asthma control As‐required FABA/ICS inhalers vs as‐required FABA inhalers | no estimate extracted | 2 studies · 2859 participants | Moderate Downgraded: imprecision |
Inhaled steroid dose As‐required FABA/ICS inhalers vs as‐required FABA inhalers | no estimate extracted | 2 studies · 2554 participants | Moderate Downgraded: imprecision |
Total systemic steroid dose As‐required FABA/ICS inhalers vs as‐required FABA inhalers | no estimate extracted | 1 study · 443 participants | Low Downgraded: imprecision |
Adverse events As‐required FABA/ICS inhalers vs as‐required FABA inhalers | OR 0.82 [0.71, 0.95] | 2 studies · 3002 participants | Moderate Downgraded: imprecision |
As‐required FABA/ICS inhalers compared to regular inhaled steroid for mild asthma
Population: mild asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations requiring systemic steroid As‐required FABA/ICS inhalers vs regular inhaled steroid | OR 0.79 [0.59, 1.07] | 4 studies · 8065 participants | Low |
Hospital admission, ED and urgent care visits As‐required FABA/ICS inhalers vs regular inhaled steroid | OR 0.63 [0.44, 0.91] | 4 studies · 8065 participants | Low |
Asthma control As‐required FABA/ICS inhalers vs regular inhaled steroid | no estimate extracted | 4 studies · 7382 participants | High |
Inhaled steroid dose As‐required FABA/ICS inhalers vs regular inhaled steroid | no estimate extracted | 4 studies · 7180 participants | Moderate |
Total systemic steroid dose As‐required FABA/ICS inhalers vs regular inhaled steroid | no estimate extracted | 2 studies · 1330 participants | Moderate |
Adverse events As‐required FABA/ICS inhalers vs regular inhaled steroid | OR 0.96 [0.82, 1.14] | 4 studies · 8072 participants | Moderate |