Cochrane · systematic review · CD008651
Stavudine or zidovudine in three‐drug combination therapy for initial treatment of HIV infection in antiretroviral‐naïve individuals
Spaulding, A, Rutherford, GW, Siegfried, N · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
d4T compared to AZT for initial treatment of HIV infection in antiretroviral‐naive individuals
Population: patients with initial treatment of HIV infection in antiretroviral‐naive individuals
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality d4T vs AZT | RR 1.36 [0.34, 5.42] | 6 studies · 1179 participants | Very low Downgraded: indirectness |
Clinical progression d4T vs AZT | RR 0.78 [0.28, 2.13] | 7 studies · 719 participants | Low Downgraded: indirectness |
Severe adverse events d4T vs AZT | RR 1.17 [0.97, 1.4] | 9 studies · 1363 participants | Low Downgraded: indirectness |
Virologic response d4T vs AZT | RR 1.03 [0.88, 1.19] | 12 studies · 2157 participants | Low Downgraded: indirectness |
Adherence/tolerability/retention d4T vs AZT | RR 0.94 [0.84, 1.05] | 12 studies · 2157 participants | Low Downgraded: indirectness |
Immunologic response d4T vs AZT | no estimate extracted | 10 studies · 1537 participants | Low Downgraded: indirectness |
Drug resistance d4T vs AZT | RR 0.66 [0.25, 1.73] | 1 study · 174 participants | Very low Downgraded: risk of bias, indirectness |