Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

249 questions in 68 reviews · Airways

current versions
No studies 249 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Antibiotics vs placebo or usual care
Relapse after index presentation ‐ not reported · acute asthma exacerbation
Antibiotics for exacerbations of asthma (2018) · Cochrane
no estimate extractedNRNo studies
Nurse‐led care vs doctor‐led care
Emergency department attendance · management of bronchiectasis
Nurse‐led versus doctor‐led care for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adults and adolescents · adults and children with chronic asthma
Inhaled steroids with and without regular salmeterol for asthma: serious adverse events (2018) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Children · adults and children with chronic asthma
Inhaled steroids with and without regular salmeterol for asthma: serious adverse events (2018) · Cochrane
no estimate extractedNRNo studies
NMES and exercise vs exercise (with or without sham NMES)
Peripheral muscle endurance/fatigability · COPD
Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease (2018) · Cochrane
no estimate extractedNRNo studies
NMES and exercise vs exercise (with or without sham NMES)
Thigh muscle size · COPD
Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease (2018) · Cochrane
no estimate extractedNRNo studies
NMES vs usual care (with or without sham NMES)
Functional performance · COPD
Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease (2018) · Cochrane
no estimate extractedNRNo studies
Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA
Exacerbations leading to intubation · people with chronic obstructive pulmonary disease
Once‐daily long‐acting beta₂‐agonists/inhaled corticosteroids combined inhalers versus inhaled long‐acting… (2018) · Cochrane
no estimate extractedNRNo studies
Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA
Physical activity measure (e.g. 6MWT) · people with chronic obstructive pulmonary disease
Once‐daily long‐acting beta₂‐agonists/inhaled corticosteroids combined inhalers versus inhaled long‐acting… (2018) · Cochrane
no estimate extractedNRNo studies
Behavioural intervention vs usual care
Exacerbations · autumn asthma exacerbations in children
Interventions for autumn exacerbations of asthma in children (2018) · Cochrane
no estimate extractedNRNo studies
Behavioural intervention vs usual care
Adverse events · autumn asthma exacerbations in children
Interventions for autumn exacerbations of asthma in children (2018) · Cochrane
no estimate extractedNRNo studies
Leukotriene receptor antagonist vs usual care
Exacerbations · autumn asthma exacerbations in children
Interventions for autumn exacerbations of asthma in children (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs placebo
Quality of life not reported · children with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Exacerbations ‐ not reported · children with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Hospitalisation ‐ not reported · children with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Serious adverse events ‐ not reported · children with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Quality of life ‐ not reported · children with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Hospitalisations ‐ not reported · adults with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Macrolides vs no intervention
Serious adverse events ‐ not reported · adults with bronchiectasis
Macrolide antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Self‐management vs usual care
Exacerbations requiring antibiotics · people with non‐cystic fibrosis bronchiectasis
Self‐management for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Self‐management vs usual care
Economic costs · people with non‐cystic fibrosis bronchiectasis
Self‐management for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Fluoroquinolones vs amoxicillin
Exacerbations · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
Head‐to‐head trials of antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Polymyxins vs aminoglycosides
Quality of life · adults aged 18 years and above with diagnosis of bronchiectasis
Head‐to‐head trials of antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Fluoroquinolones vs amoxicillin
Quality of life · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
Head‐to‐head trials of antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
Polymyxins vs aminoglycosides
Exacerbation · adults aged 18 years and above with diagnosis of bronchiectasis
Head‐to‐head trials of antibiotics for bronchiectasis (2018) · Cochrane
no estimate extractedNRNo studies
MgSO4 vs SABA
Lung function · adults and children with acute exacerbation of asthma
Inhaled magnesium sulfate in the treatment of acute asthma (2017) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Incidence of acute exacerbations of bronchiectasis ‐ not reported · people with bronchiectasis
Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis (2017) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of acute exacerbation of bronchiectasis ‐ not reported · people with bronchiectasis
Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis (2017) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Incidence of hospitalisation ‐ not reported · people with bronchiectasis
Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis (2017) · Cochrane
no estimate extractedNRNo studies
ICS dose reduction vs no change
Steroid‐related AEs ‐ not reported · adults with asthma
Stepping down the dose of inhaled corticosteroids for adults with asthma (2017) · Cochrane
no estimate extractedNRNo studies
ICS dose reduction vs no change
Exacerbations requiring hospitalisation ‐ not reported · adults with asthma
Stepping down the dose of inhaled corticosteroids for adults with asthma (2017) · Cochrane
no estimate extractedNRNo studies
PAAP plus education vs education alone
Serious adverse events (including death). · adults with asthma
Personalised asthma action plans for adults with asthma (2017) · Cochrane
no estimate extractedNRNo studies
PAAP plus education vs education alone
Lung function. · adults with asthma
Personalised asthma action plans for adults with asthma (2017) · Cochrane
no estimate extractedNRNo studies
PAAP plus education vs education alone
Days lost from work or study. · adults with asthma
Personalised asthma action plans for adults with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Airway bypass stents vs control
Cost effectiveness · Participants suffering from chronic obstructive pulmonary disease
Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease (2017) · Cochrane
no estimate extractedNRNo studies
Intrabronchial valves vs control
Cost‐ effectiveness · Participants suffering from chronic obstructive pulmonary disease
Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease (2017) · Cochrane
no estimate extractedNRNo studies
AeriSeal vs control
Change from baseline in lung function parameters other than FEV1 · Participants suffering from chronic obstructive pulmonary disease
Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease (2017) · Cochrane
no estimate extractedNRNo studies
Vapour ablation vs control
Cost effectiveness · Participants suffering from chronic obstructive pulmonary disease
Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease (2017) · Cochrane
no estimate extractedNRNo studies
AeriSeal vs control
Cost effectiveness end of · Participants suffering from chronic obstructive pulmonary disease
Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease (2017) · Cochrane
no estimate extractedNRNo studies
Multimedia training vs control versus usual care
Other outcomes · adults and children with asthma
Interventions to improve inhaler technique for people with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Feedback device vs control versus usual care
Other outcomes · adults and children with asthma
Interventions to improve inhaler technique for people with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Enhanced education vs control versus usual care
Other outcomes · adults and children with asthma
Interventions to improve inhaler technique for people with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making vs usual care
Parent/patient satisfaction · adults and children with asthma
Shared decision‐making for people with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making vs usual care
Adverse events (all) · adults and children with asthma
Shared decision‐making for people with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events · adolescents with asthma
Lay‐led and peer support interventions for adolescents with asthma (2017) · Cochrane
no estimate extractedNRNo studies
Tai Chi and breathing exercise vs breathing exercise
CI: Confidence interval · chronic obstructive pulmonary disease (COPD)
Tai Chi for chronic obstructive pulmonary disease (COPD) (2016) · Cochrane
no estimate extractedNRNo studies
Tai Chi and exercise vs exercise
CI: Confidence interval · chronic obstructive pulmonary disease (COPD)
Tai Chi for chronic obstructive pulmonary disease (COPD) (2016) · Cochrane
no estimate extractedNRNo studies
Tai Chi vs usual care
CI: Confidence interval · chronic obstructive pulmonary disease (COPD)
Tai Chi for chronic obstructive pulmonary disease (COPD) (2016) · Cochrane
no estimate extractedNRNo studies
Breathing exercises as part of a package of interventions vs control
Serious adverse events · children with asthma
Breathing exercises for children with asthma (2016) · Cochrane
no estimate extractedNRNo studies
Cognitive behavioural therapy vs usual care
Asthma exacerbations requiring at least a course of oral steroids · adults and adolescents with asthma
Cognitive behavioural therapy (CBT) for adults and adolescents with asthma (2016) · Cochrane
no estimate extractedNRNo studies