evidence/gaps
Cochrane · systematic review · CD006922

Inhaled steroids with and without regular salmeterol for asthma: serious adverse events

Cates, CJ, Schmidt, S, Ferrer, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library

Airways3 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 10%Moderate 7 · 70%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Serious adverse events (SAEs) in adults and children

Population: adults and children with chronic asthma
10 questions
OutcomeEffectEvidenceStatus / GRADE
Adults and adolescents
no estimate extractedNRNo studies
All‐cause mortality
OR 0.8 [0.36, 1.78]41 studies · 27951 participantsModerate
Downgraded: imprecision
All‐cause non‐fatal SAEc
OR 1.14 [0.97, 1.33]41 studies · 27951 participantsModerate
Downgraded: imprecision
Asthma‐related mortality
no estimate extracted41 studies · 27951 participantsModerate
Downgraded: imprecision
Asthma‐related non‐fatal SAEc
OR 1.15 [0.83, 1.59]41 studies · 27951 participantsLow
Downgraded: imprecision
Children
no estimate extractedNRNo studies
All‐cause mortality
no estimate extracted8 studies · 8453 participantsModerate
Downgraded: imprecision
All‐cause non‐fatal SAEc
OR 1.04 [0.73, 1.48]8 studies · 8453 participantsModerate
Downgraded: imprecision
Asthma‐related mortality
no estimate extracted8 studies · 8453 participantsModerate
Downgraded: imprecision
Asthma‐related non‐fatal SAEc
OR 1.25 [0.72, 2.16]8 studies · 8453 participantsModerate
Downgraded: imprecision