Cochrane · systematic review · CD012406
Macrolide antibiotics for bronchiectasis
Kelly, C, Chalmers, JD, Crossingham, I, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
22
current version
GRADE rated
15
No studies
7
Included studies
NR
No studies 7 · 31.8%Ungraded 0 · 0%Very low 1 · 4.5%Low 9 · 40.9%Moderate 5 · 22.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Macrolides compared with placebo for adults with bronchiectasis
Population: adults with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
≥ 1 exacerbation Macrolides vs placebo | OR 0.34 [0.22, 0.54] | 3 studies · 341 participants | Moderate |
Hospitalisation: all cause Macrolides vs placebo | OR 0.56 [0.19, 1.62] | 2 studies · 151 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events Macrolides vs placebo | OR 0.49 [0.2, 1.23] | 3 studies · 326 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Macrolides vs placebo | no estimate extracted | 7 studies · 540 participants | Low Downgraded: risk of bias, imprecision |
Quality of life: endpoint Macrolides vs placebo | no estimate extracted | 1 study · 68 participants | Moderate Downgraded: risk of bias, imprecision |
Quality of life: change Macrolides vs placebo | no estimate extracted | 4 studies · 305 participants | Low Downgraded: risk of bias, imprecision |
Macrolides compared with no intervention for adults with bronchiectasis
Population: adults with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
≥ 1 exacerbation Macrolides vs no intervention | OR 0.31 [0.08, 1.15] | 1 study · 43 participants | Moderate |
Hospitalisations ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |
Mortality Macrolides vs no intervention | no estimate extracted | 2 studies · 88 participants | Very low |
QoL SGRQ: endpoint total score Scale from 0 to 100 Macrolides vs no intervention | no estimate extracted | 2 studies · 89 participants | Moderate |
QoL SGRQ: change in total score Scale from 0 to 100 Macrolides vs no intervention | no estimate extracted | 1 study · 30 participants | Moderate |
Macrolides compared with placebo for children with bronchiectasis
Population: children with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation frequency Macrolides vs placebo | IRR 0.5 | 1 study · 89 participants | Low Downgraded: imprecision |
Hospitalisation: all‐cause Macrolides vs placebo | OR 0.28 [0.07, 1.11] | 1 study · 89 participants | Low Downgraded: imprecision |
Serious adverse events Macrolides vs placebo | OR 0.43 [0.17, 1.05] | 1 study · 89 participants | Low Downgraded: imprecision |
Mortality Macrolides vs placebo | no estimate extracted | 1 study · 42 participants | Low Downgraded: risk of bias, imprecision |
Quality of life not reported Macrolides vs placebo | no estimate extracted | NR | No studies |
Macrolides compared with no intervention for children with bronchiectasis
Population: children with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |
Hospitalisation ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |
Mortality Macrolides vs no intervention | no estimate extracted | 1 study · 34 participants | Low |
Quality of life ‐ not reported Macrolides vs no intervention | no estimate extracted | NR | No studies |