Cochrane · systematic review · CD012590
Head‐to‐head trials of antibiotics for bronchiectasis
Kaehne, A, Milan, SJ, Felix, LM, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
9
No studies
4
Included studies
NR
No studies 4 · 30.8%Ungraded 0 · 0%Very low 5 · 38.5%Low 4 · 30.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fluoroquinolones compared to amoxicillin for bronchiectasis
Population: adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations Fluoroquinolones vs amoxicillin | no estimate extracted | NR | No studies |
Serious adverse events Fluoroquinolones vs amoxicillin | no estimate extracted | 2 studies · 83 participants | Low Downgraded: risk of bias |
Response rate ‐ treatment failure Fluoroquinolones vs amoxicillin | OR 0.07 [0.01, 0.32] | 2 studies · 83 participants | Low Downgraded: risk of bias |
Response rate ‐ microbiological response Fluoroquinolones vs amoxicillin | Peto OR 20.09 [2.83, 142.59] | 1 study · 16 participants | Low Downgraded: risk of bias |
Response rate ‐ improvement in sputum purulence (excellent) Fluoroquinolones vs amoxicillin | OR 2.35 [0.96, 5.72] | 2 studies · 83 participants | Very low Downgraded: risk of bias |
Deaths Fluoroquinolones vs amoxicillin | no estimate extracted | 2 studies · 83 participants | Low Downgraded: risk of bias |
Quality of life Fluoroquinolones vs amoxicillin | no estimate extracted | NR | No studies |
Polymyxins compared to aminoglycosides for bronchiectasis
Population: adults aged 18 years and above with diagnosis of bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation Polymyxins vs aminoglycosides | no estimate extracted | NR | No studies |
Serious adverse events Polymyxins vs aminoglycosides | no estimate extracted | 1 study · 20 participants | Very low |
Response rate ‐ improvement in sputum purulence Polymyxins vs aminoglycosides | OR 0.16 [0.01, 3.85] | 1 study · 20 participants | Very low |
Response rate ‐ P aeruginosa eradication Polymyxins vs aminoglycosides | OR 1.4 [0.36, 5.35] | 1 study · 35 participants | Very low |
Deaths Polymyxins vs aminoglycosides | no estimate extracted | 1 study · 20 participants | Very low |
Quality of life Polymyxins vs aminoglycosides | no estimate extracted | NR | No studies |