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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
15,213 questions in 2,394 reviews
current versionsNo studies 15,213 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Statin vs metformin Adverse effects · women with polycystic ovary syndrome not actively trying to conceive Statins for women with polycystic ovary syndrome not actively trying to conceive (2023) · Cochrane | no estimate extracted | NR | No studies |
Statin vs placebo Improvement in hirsutism · women with polycystic ovary syndrome not actively trying to conceive Statins for women with polycystic ovary syndrome not actively trying to conceive (2023) · Cochrane | no estimate extracted | NR | No studies |
Statin vs placebo Improvement in acne severity · women with polycystic ovary syndrome not actively trying to conceive Statins for women with polycystic ovary syndrome not actively trying to conceive (2023) · Cochrane | no estimate extracted | NR | No studies |
Extracorporeal shock wave therapy vs control Time to return to normal activities · adolescents and adults with acute fractures in tibia and femur Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Extracorporeal shock wave therapy vs control Time to fracture union · adolescents and adults with acute fractures in tibia and femur Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Extracorporeal shock wave therapy vs control Adverse events · adolescents and adults with acute fractures in tibia and femur Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Low‐intensity pulsed ultrasound vs control Quantitative functional improvement Using PROMs · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius,… Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Extracorporeal shock wave therapy vs control Participant‐reported quality of life · adolescents and adults with acute fractures in tibia and femur Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Extracorporeal shock wave therapy vs control Quantitative functional improvement · adolescents and adults with acute fractures in tibia and femur Ultrasound and shockwave therapy for acute fractures in adults (2023) · Cochrane | no estimate extracted | NR | No studies |
Surgical vs non‐surgical management Function in the short term · people aged over 14 years with displaced intra‐articular calcaneal fractures Surgical versus non‐surgical interventions for displaced intra‐articular calcaneal fractures (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs autologous fascial slings Subjective cure or improvement of urinary incontinence: at 12 months · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs retropubic minimally‐invasive slings Number of women with dyspareunia · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs retropubic minimally‐invasive slings Quality of life: at 12 months · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs autologous fascial slings Patient‐reported pain: at more than 24 months · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs autologous fascial slings Number of women with urinary retention · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs autologous fascial slings Quality of life: at 12 months · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs autologous fascial slings Number of women requiring repeat continence surgery · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Single‐incision slings vs retropubic minimally‐invasive slings Patient‐reported pain: at more than 24 months · women with urinary incontinence Single‐incision sling operations for urinary incontinence in women (2023) · Cochrane | no estimate extracted | NR | No studies |
Anti‐vascular endothelial growth factor (anti‐VEGF) with or without pan‐retinal photocoagulation (PRP) vs PRP alone Loss of 3 or more lines of ETDRS visual acuity ‐ not reported · people with proliferative diabetic retinopathy Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 3: Efficacy and safety of IVT pegcetacoplan 4‐weekly (monthly) vs sham Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD Complement inhibitors for age‐related macular degeneration (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 3: Efficacy and safety of IVT pegcetacoplan 4‐weekly (monthly) vs sham Change in quality of life at 1 year (NEI VFQ‐25 composite score) · adults with GA due to AMD Complement inhibitors for age‐related macular degeneration (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 4: Efficacy and safety of IVT pegcetacoplan 8‐weekly (every other month) vs sham Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD Complement inhibitors for age‐related macular degeneration (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 4: Efficacy and safety of IVT pegcetacoplan 8‐weekly (every other month) vs sham Change in quality of life at 1 year (NEI VFQ‐25 composite score) · adults with GA due to AMD Complement inhibitors for age‐related macular degeneration (2023) · Cochrane | no estimate extracted | NR | No studies |
Exercise therapy vs sham/placebo treatment Perceived recovery · acute non‐specific LBP Exercise therapy for treatment of acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
Exercise therapy vs sham/placebo treatment Adverse events · acute non‐specific LBP Exercise therapy for treatment of acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
Exercise therapy vs no treatment Perceived recovery · acute non‐specific LBP Exercise therapy for treatment of acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
Exercise therapy vs no treatment Adverse events · acute non‐specific LBP Exercise therapy for treatment of acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Postoperative pancreatic fistula (grade B or C) · people undergoing pancreaticoduodenectomy Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Quality of life · people undergoing pancreaticoduodenectomy Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cost‐effectiveness · people undergoing pancreaticoduodenectomy Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cost‐effectiveness · people undergoing distal pancreatectomy Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery (2023) · Cochrane | no estimate extracted | NR | No studies |
Mammography in combination with breast ultrasonography vs mammography alone Outcomes after 1‐ to 2‐year · s of women with dense and non‐dense breasts Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane | no estimate extracted | NR | No studies |
Mammography in combination with breast ultrasonography vs mammography alone Outcomes after 1‐ to 2‐year · breast cancer screening in women at average risk with dense breasts Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane | no estimate extracted | NR | No studies |
Mammography in combination with breast ultrasonography vs mammography alone Breast cancer mortality · s of women with dense and non‐dense breasts Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane | no estimate extracted | NR | No studies |
Mammography in combination with breast ultrasonography vs mammography alone Outcomes after 1‐ to 2‐year · breast cancer screening (non‐dense breasts) Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane | no estimate extracted | NR | No studies |
Mammography in combination with breast ultrasonography vs mammography alone All‐cause mortality · s of women with dense and non‐dense breasts Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane | no estimate extracted | NR | No studies |
Hormonal therapy vs placebo or no intervention Estrogen + progestogens · symptomatic or early postmenopausal womena Hormone therapy for sexual function in perimenopausal and postmenopausal women (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Clinically significant reduction in pain · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea… Interventions for the symptoms and signs resulting from jellyfish stings (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Retreatment with the same intervention at 0 to 1 hour · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea… Interventions for the symptoms and signs resulting from jellyfish stings (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Retreatment with the alternative intervention at 0 to 1 hour · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea… Interventions for the symptoms and signs resulting from jellyfish stings (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Dermatological signs up to 1 week after the sting · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea… Interventions for the symptoms and signs resulting from jellyfish stings (2023) · Cochrane | no estimate extracted | NR | No studies |
McKenzie therapy vs manual therapy Adverse events · patients with non‐specific acute and subacute low back pain The McKenzie method for (sub)acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
McKenzie therapy vs other interventions Pain intensity: short‐term (closest to 2 weeks) · patients with non‐specific acute and subacute low back pain The McKenzie method for (sub)acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
McKenzie therapy vs other interventions Pain intensity: intermediate‐term (closest to 3 months) · patients with non‐specific acute and subacute low back pain The McKenzie method for (sub)acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
McKenzie therapy vs other interventions Adverse events · patients with non‐specific acute and subacute low back pain The McKenzie method for (sub)acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
McKenzie therapy vs minimal intervention Adverse events · patients with non‐specific acute and subacute low back pain The McKenzie method for (sub)acute non‐specific low back pain (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral stimulation vs standard care Time (days) spent in NICU ‐ not reported · preterm infants Oral stimulation for promoting oral feeding in preterm infants (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral stimulation vs standard care Duration (days) of parenteral nutrition ‐ not reported · preterm infants Oral stimulation for promoting oral feeding in preterm infants (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral stimulation vs non‐oral intervention Time (days) spent in NICU ‐ not reported · preterm infants Oral stimulation for promoting oral feeding in preterm infants (2023) · Cochrane | no estimate extracted | NR | No studies |
Immunomodulatory interventions vs placebo Seizure freedom · people with focal epilepsy Immunomodulatory interventions for focal epilepsy (2023) · Cochrane | no estimate extracted | NR | No studies |