Cochrane · systematic review · CD008579

Ultrasound and shockwave therapy for acute fractures in adults

Searle, HKC, Lewis, SR, Coyle, C, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Bone, Joint and Muscle TraumaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
6
Included studies
NR
No studies 6 · 42.9%Ungraded 0 · 0%Very low 6 · 42.9%Low 1 · 7.1%Moderate 1 · 7.1%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Low‐intensity pulsed ultrasound compared to control for acute fractures in adults

Population: acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid, mandibular, rib), complete lower limb fractures (fifth metatarsal, tibia, femur, lateral malleolus) and stress fractures
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported quality of life (medium term) QoL measured using SF‐36 PCS ranging from 0 to 100; high scores indicate better quality of life
Low‐intensity pulsed ultrasound vs control
no estimate extracted3 studies · 393 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Quantitative functional improvement Using PROMs
Low‐intensity pulsed ultrasound vs control
no estimate extractedNRNo studies
Time to return to normal activities (work) Number of days
Low‐intensity pulsed ultrasound vs control
no estimate extracted2 studies · 370 participantsLow
Downgraded: risk of bias, imprecision
Time to fracture union (days)
Low‐intensity pulsed ultrasound vs control
no estimate extracted11 studies · 887 participantsVery low
Downgraded: risk of bias, inconsistency
Pain (short term): using VAS (range 0 to 10); higher values indicate worse pain
Low‐intensity pulsed ultrasound vs control
no estimate extracted2 studies · 148 participantsVery low
Downgraded: imprecision, inconsistency
Delayed or non‐union (medium term)
Low‐intensity pulsed ultrasound vs control
RR 1.25 [0.5, 3.09]7 studies · 746 participantsModerate
Downgraded: imprecision
Adverse events Reported as skin irritation
Low‐intensity pulsed ultrasound vs control
RR 0.94 [0.06, 14.65]1 study · 101 participantsVery low
Downgraded: risk of bias, imprecision

Extracorporeal shock wave therapy compared to control for acute fractures in adults

Population: adolescents and adults with acute fractures in tibia and femur
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported quality of life
Extracorporeal shock wave therapy vs control
no estimate extractedNRNo studies
Quantitative functional improvement
Extracorporeal shock wave therapy vs control
no estimate extractedNRNo studies
Time to return to normal activities
Extracorporeal shock wave therapy vs control
no estimate extractedNRNo studies
Time to fracture union
Extracorporeal shock wave therapy vs control
no estimate extractedNRNo studies
Pain (medium term): using VAS (range 0 to 10); higher values indicate worse pain
Extracorporeal shock wave therapy vs control
no estimate extracted1 study · 57 participantsVery low
Downgraded: risk of bias, imprecision
Delayed or non‐union (medium term)
Extracorporeal shock wave therapy vs control
RR 0.56 [0.15, 2.01]1 study · 57 participantsVery low
Downgraded: risk of bias, imprecision
Adverse events
Extracorporeal shock wave therapy vs control
no estimate extractedNRNo studies