Cochrane · systematic review · CD009632
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk
Glechner, A, Wagner, G, Mitus, JW, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
27
current version
GRADE rated
22
No studies
5
Included studies
NR
No studies 5 · 18.5%Ungraded 0 · 0%Very low 1 · 3.7%Low 4 · 14.8%Moderate 6 · 22.2%High 11 · 40.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mammography in combination with breast ultrasonography versus mammography alone for breast cancer screening in mixed populations of women with dense and non‐dense breasts
Population: s of women with dense and non‐dense breasts
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes after 1‐ to 2‐year Mammography in combination with breast ultrasonography vs mammography alone | no estimate extracted | NR | No studies |
Breast cancer mortality Mammography in combination with breast ultrasonography vs mammography alone | no estimate extracted | NR | No studies |
All‐cause mortality Mammography in combination with breast ultrasonography vs mammography alone | no estimate extracted | NR | No studies |
Incremental cancer detection: RCT Mammography in combination with breast ultrasonography vs mammography alone | RR 1.54 [1.22, 1.94] | 1 study · 72717 participants | High |
Incremental cancer detection: cohort studies Mammography in combination with breast ultrasonography vs mammography alone | RR 1.35 [0.92, 1.98] | 83469 participants | Low Downgraded: risk of bias |
Incremental detection of invasive cancers: RCT Mammography in combination with breast ultrasonography vs mammography alone | RR 0.95 [0.82, 1.09] | 1 study · 301 participants | Low Downgraded: imprecision |
Incremental detection of invasive cancers: cohort studies Mammography in combination with breast ultrasonography vs mammography alone | RR 1 [0.95, 1.06] | 571 participants | Very low Downgraded: risk of bias, imprecision |
Interval cancer Mammography in combination with breast ultrasonography vs mammography alone | RR 0.5 [0.29, 0.89] | 1 study · 72717 participants | High |
Lymph node status Mammography in combination with breast ultrasonography vs mammography alone | RR 0.53 [0.33, 0.86] | 1 study · 214 participants | Moderate Downgraded: imprecision |
False‐positive rate Mammography in combination with breast ultrasonography vs mammography alone | RR 1.43 [1.37, 1.5] | 1 study · 70825 participants | High |
False‐negative rate Mammography in combination with breast ultrasonography vs mammography alone | RR 0.39 [0.23, 0.66] | 1 study · 354 participants | Moderate Downgraded: imprecision |
Rate of biopsies Mammography in combination with breast ultrasonography vs mammography alone | RR 2.49 [2.28, 2.72] | 1 study · 72717 participants | High |
Mammography in combination with breast ultrasonography versus mammography alone in women with dense breasts
Population: breast cancer screening in women at average risk with dense breasts
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes after 1‐ to 2‐year Mammography in combination with breast ultrasonography vs mammography alone | no estimate extracted | NR | No studies |
Incremental cancer detection in women with dense breasts: RCT Mammography in combination with breast ultrasonography vs mammography alone | RR 1.65 [1, 2.72] | 1 study · 11390 participants | High |
Incremental cancer detection in women with dense breasts: cohort studies Mammography in combination with breast ultrasonography vs mammography alone | RR 1.78 [1.23, 2.56] | 50327 participants | Moderate Downgraded: risk of bias |
Incremental detection of invasive cancers Mammography in combination with breast ultrasonography vs mammography alone | RR 0.91 [0.67, 1.24] | 1 study · 65 participants | Low Downgraded: imprecision |
Interval cancer Mammography in combination with breast ultrasonography vs mammography alone | RR 0.29 [0.08, 1.05] | 1 study · 11390 participants | High |
False‐positive rate in women with dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 1.76 [1.58, 1.96] | 1 study · 11312 participants | High |
False‐negative rate in women with dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 0.23 [0.07, 0.78] | 1 study · 78 participants | Moderate Downgraded: imprecision |
Biopsy rate in women with dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 2.73 [2.24, 3.34] | 1 study · 11390 participants | High |
Mammography in combination with breast ultrasonography versus mammography alone in women with non‐dense breasts
Population: breast cancer screening (non‐dense breasts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes after 1‐ to 2‐year Mammography in combination with breast ultrasonography vs mammography alone | no estimate extracted | NR | No studies |
Incremental cancer detection for women with non‐dense breasts: RCT Mammography in combination with breast ultrasonography vs mammography alone | RR 1.93 [1.01, 3.68] | 1 study · 7823 participants | Moderate Downgraded: imprecision |
Incremental cancer detection for women with non‐dense breasts: cohort studies Mammography in combination with breast ultrasonography vs mammography alone | RR 1.13 [0.85, 1.49] | 40636 participants | Low Downgraded: risk of bias |
Interval cancer Mammography in combination with breast ultrasonography vs mammography alone | RR 0.22 [0.05, 1.03] | 1 study · 7823 participants | High |
False‐positive rate in women with non‐dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 1.36 [1.18, 1.56] | 1 study · 7771 participants | High |
False‐negative rate in women with non‐dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 0.18 [0.04, 0.74] | 1 study · 52 participants | Moderate Downgraded: imprecision |
Biopsy rate in women with non‐dense breasts Mammography in combination with breast ultrasonography vs mammography alone | RR 2.58 [1.96, 3.4] | 1 study · 7823 participants | High |