Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, amalgam had a higher risk of secondary caries than GIC (RR 1.79, 95% CI 1.04-3.09; low certainty).
1 finding from 1 review
Not applicable (no eligible studies) · Adults with coronal (crown) dental caries in permanent teeth
No eligible studies assessed SDF for coronal caries in adults; this is an evidence gap identified by the review.
1 finding from 1 review
MMP-20 expression · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-20 expression was found between irradiated and non-irradiated carious dentin (very low certainty).
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Probiotic mouthwash has inconsistent effects on Mutans streptococci colony counts versus blank control; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Treating traumatic dental injuries reduces their negative impact on OHRQoL in adolescents (narrative synthesis; included review reports low certainty; no pooled estimate or GRADE rating by the umbrella review).
1 finding from 1 review
Salivary flow rate (unstimulated) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
codex
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with ceramic restorations was 5.59%.
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with radiographic assessment was 4.95%.
2 findings from 1 review
Proportion 4.95 [2.43, 8.29]
5 studies · 1853 participants
GRADE not reported
Proportion 5.66 [3.71, 7.99]
24 studies · 6581 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish (gold standard) did not differ significantly from control (SMD -0.25, 95% CI -0.51 to 0.02); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported no negative oral health-related quality-of-life impact from uncomplicated traumatic dental injuries.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Periapical pathosis incidence · Vital teeth
The pooled incidence with > 5–10 years of follow-up was 3.88%.
1 finding from 1 review
Gingival index (GI) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash probably reduces the Gingival Index versus placebo in the short term (WMD -0.45, 95% CI -0.70 to -0.20; low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian elderly
Evidence on functional edentulism and OHRQoL is inconsistent across two studies (very low certainty).
2 findings from 1 review
Functional edentulism vs none: studies show inconsistency; one study found a significant association (Pushpanjali 2013), one did not (Shivakumar 2018); 368 participants, 2 observational studies; Very low certainty (Fig…
2 studies · 368 participants
Very low
SMD 0.31 [-0.37, 0.99]
4 studies · 1146 participants
Very low
Barriers and facilitators to implementation of the integration strategy (qualitative) · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Key barriers to implementing integration strategies were time/staff/resource constraints and lack of organisational support, while facilitators were professionals' knowledge and attitudes and supportive governance/leadership (qualitative; ungraded).
1 finding from 1 review
CA VI concentration · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
CA VI concentration was lower in participants with caries (SMD -0.66, 95% CI -1.00 to -0.32; 2 studies, 141 participants); GRADE was not reported.
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 1.1% incidence with zinc polycarboxylate permanent cement.
1 finding from 1 review
Proportion 1.1
1 study
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from fluoride varnish (SMD -0.31, 95% CI -0.71 to 0.09); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Dental caries · Children (mixed dentition; baseline about 8 years)
In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).
1 finding from 1 review
RR 1.08 [1.04, 1.12]
4 studies
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from CPP-ACP (SMD -0.38, 95% CI -0.87 to 0.11; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review