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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

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No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Longer follow-up vs Shorter follow-up

Annual increment in DMFT (D3) · Children and adolescents with permanent dentition

Not adjusted meta-regression beta was 0.18 per additional follow-up year.

5 findings from 1 review
  • Caries Progression Rates Revisited: A Systematic Review. 2019 All outcomes
    Per additional year of follow-up · Western or comparable populations · Not adjusted
    Meta-regression beta per year of follow-up 0.18 [-0.04, 0.40]
    13 studies · 24753 participants
    GRADE not reported
  • Caries Progression Rates Revisited: A Systematic Review. 2019 All outcomes
    Per additional year of follow-up · Western or comparable populations · Adjusted for bitewings and age at baseline
    Meta-regression beta per year of follow-up 0.18 [0.02, 0.35]
    13 studies · 24753 participants
    GRADE not reported
  • Caries Progression Rates Revisited: A Systematic Review. 2019 All outcomes
    Per additional year of follow-up · Western or comparable populations · Adjusted for bitewings age at baseline and baseline caries experience
    Meta-regression beta per year of follow-up 0.23 [0.06, 0.40]
    13 studies · 24753 participants
    GRADE not reported
Show 2 more findings
  • Caries Progression Rates Revisited: A Systematic Review. 2019 All outcomes
    Per additional year of follow-up · Western or comparable populations · Adjusted for groups 1-4 including relevance of evidence and risk of bias
    Meta-regression beta per year of follow-up -0.04 [-0.34, 0.26]
    13 studies · 24753 participants
    GRADE not reported
  • Caries Progression Rates Revisited: A Systematic Review. 2019 All outcomes
    Per additional year of follow-up · Western or comparable populations · Adjusted for groups 1-3 including decade and preventive intervention
    Meta-regression beta per year of follow-up 0.07 [-0.24, 0.39]
    13 studies · 24753 participants
    GRADE not reported

1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

It is very uncertain whether 1700 to 2200 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1000 to 1250 ppm F toothpaste (very low certainty).

1 finding from 1 review

No intervention (single-arm cohort estimates) vs No comparator

First dentine caries incidence rate per person-year at risk (D3) · Caries-free children and adolescents with permanent dentition

Sánchez-Pérez et al. 2010 reported an incidence rate of 0.07 per person-year at risk.

16 findings from 1 review
Show 13 more findings

2400 to 2800 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), cold response measurement (time in seconds) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… may leads to higher postoperative hypersensitivity (POH), cold response measurement… compared with no liner (resin-based composite bonded directly to the tooth) (low certainty).

1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (gingival index) compared with flossing plus toothbrushing (very low certainty).

2 findings from 1 review

38% silver diamine fluoride vs Fluoride varnish

Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)

38% SDF solution (applied annually) may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.64, 95% CI 0.04 to 9.66; very low certainty).

1 finding from 1 review

1.23% APF gel vs CPP-ACP

Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)

1.23% APF gel was probably more effective than 10% CPP-ACP paste for arrest or reversal of any-coronal carious lesions (RR 2.19, 95% CI 1.83 to 2.61; moderate certainty).

1 finding from 1 review

Intervention not reported

Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes

Caries prevalence was highest in South American studies at 84% (95% CI 0.67 to 0.94); certainty not graded.

1 finding from 1 review

Wooden cleaning stick plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

2 findings from 1 review

Residence in low-contamination area (approx. 5-15 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)

Dental caries · Children aged 12-15 years (adolescents)

In adolescents (12-15 y) from a low-contamination area, individual studies reported higher DMFT/dmft in exposed than non-exposed children; not pooled (ungraded).

2 findings from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs Sealant

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing may not differ from Sealant for arrest or reversal of occlusal carious lesions (RR 0.98, 95% CI 0.84 to 1.14; low certainty).

1 finding from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).

2 findings from 1 review · compare the 2 reviews

Intervention not reported

Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes

Caries prevalence in Asian studies was 67% (95% CI 0.43 to 0.85); certainty not graded.

1 finding from 1 review

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether oral irrigation plus toothbrushing changes gingivitis (gingival index) compared with flossing plus toothbrushing (very low certainty).

2 findings from 1 review

Residence in weakly contaminated area (approx. 1-5 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)

Dental caries · Children aged 12-15 years (adolescents)

In adolescents (12-15 y) from weakly contaminated areas, individual studies mostly reported higher DMFT/dmft in exposed children but with wide variation; the review did not pool the data (ungraded).

9 findings from 1 review
Show 6 more findings

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)

1055 to 1100 ppm F toothpaste may leads to lower proportion developing new caries compared with 500 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

color contrast: black vs dark brown/light brown/yellow vs hardness contrast: soft vs medium/hard

total microbial load (log10 CFU) · humans with open primary dentine caries

In one study, hardness category differences exceeded color category differences; no meta-analysis was conducted.

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste probably leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).

1 finding from 1 review