Non-Cochrane · prognostic · PM31070943

Caries Progression Rates Revisited: A Systematic Review.

Hummel R, Akveld N A E, Bruers J J M, et al. · Journal of dental research · 2019 · PubMed · doi:10.1177/0022034519847953

Oral HealthDental cariesAMSTAR 2: not applicable
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
47
current version
GRADE rated
0
No studies
0
Included studies
43
linked below
No studies 0 · 0%Ungraded 47 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Review question

ElementPlanned (methods)Found (results)
PopulationChildren and adolescents up to age 21 y in Western (or comparable) populations; primary and permanent dentition; closed cohorts with >=2 full-mouth examinations, first examination after 1974 and second before age 22 y, >=3 y follow-up43 studies, 56,376 participants (systematic review); 32 studies, 39,429 participants (meta-analyses); primary dentition n=10 studies, permanent dentition n=38 studies
InterventionLongitudinal follow-up over time (natural caries progression); no assigned intervention (prospective, retrospective, cohort and intervention studies eligible; cross-sectional and case-control excluded)Longitudinal follow-up over time (>=3 y); natural caries progression (n=43 studies)
ComparisonWithin-cohort change from baseline to follow-up; no between-group comparator (descriptive natural-history review)Within-cohort baseline vs follow-up; no between-group comparator
Outcomes(1) Annual decline in percentage of caries-free children/adolescents; (2) annual increment in dmfs/DMFS; (3) annual increment in dmft/DMFT; caries incidence rate (first D3 lesion) per person-year at riskPermanent dentition: caries-free decline (18 studies), DMFS increment (26), DMFT increment (14), pooled caries incidence rate 0.11 (0.09-0.13) per person-year at risk (15 studies); DMFS increment per year 0.43 (22 studies), DMFT increment per year 0.18 (13 studies). Primary dentition: caries-free decline (6), dmfs increment (7), dmft increment (4) - not pooled
Study designsWestern Europe, North America, Australia, New Zealand (or comparable Western populations)Western (or comparable) populations (study-level details in Appendix Tables 4-9)
TimingFollow-up >=3 y; annual progression rates; incidence per person-year at riskFollow-up >=3 y (annual rates); caries incidence per person-year at risk

Search date: 16 April 2018. Databases: MEDLINE-PubMed; Embase; CINAHL; Cochrane Library

Questions and results

No intervention (single-arm cohort estimates) vs No comparator

Population: Caries-free children and adolescents with permanent dentition
19 questions
OutcomeEffectEvidenceStatus / GRADE
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Sánchez-Pérez et al. 2010 reported an incidence rate of 0.07 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.07 [0.06, 0.08]1 studyUngraded
Annual increment in dmfs (primary dentition)
Per year of follow-up
Population: Children (primary dentition, d3), Western or comparable populations
In the primary dentition, the annual dmfs increment ranged from -1.0 to 1.0 across 7 studies; values were inconsistent because of tooth exfoliation and could not be pooled (ungraded).
Source: Results 'Primary Dentition'; Table 2 · same question in other reviews
-1.0 to 1.07 studies · 5896 participantsUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Foster Page et al. 2012 reported an incidence rate of 0.14 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.14 [0.12, 0.16]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Kruger et al. 1998 reported an incidence rate of 0.20 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.20 [0.18, 0.23]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Li et al. 2017 reported an incidence rate of 0.11 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.11 [0.10, 0.12]1 studyUngraded
Annual decline in percentage of caries-free children (primary dentition, d3)
Annual (studies with >=3 y follow-up)
Population: Children (primary dentition, d3), Western or comparable populations
In the primary dentition, the annual decline in the percentage of caries-free children ranged from 3.8% to 12.2% across 6 studies (descriptive range, no pooled estimate; ungraded).
Source: Results 'Primary Dentition'; Table 2 · same question in other reviews
3.8% to 12.2%6 studies · 3318 participantsUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Masood et al. 2012 reported an incidence rate of 0.06 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.06 [0.06, 0.06]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Ruiken et al. 1986 reported an incidence rate of 0.14 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.14 [0.13, 0.15]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Lenkkeri et al. 2012 reported an incidence rate of 0.16 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.16 [0.15, 0.17]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
van Rijkom et al. 2004 reported an incidence rate of 0.05 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.05 [0.05, 0.05]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Across 15 studies the pooled incidence rate was 0.11 per person-year at risk (random effects; I²=100%).
Source: Figure 2; Figure 2 caption · same question in other reviews
Incidence rate per person-year at risk 0.11 [0.09, 0.13]15 studies · 10768 participantsUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Karjalainen et al. 1994 reported an incidence rate of 0.14 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.14 [0.13, 0.16]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Virtanen 2001 reported an incidence rate of 0.12 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.12 [0.12, 0.12]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
David et al. 2006 reported an incidence rate of 0.21 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.21 [0.18, 0.25]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Swedberg et al. 1997a reported an incidence rate of 0.12 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.12 [0.11, 0.13]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Heinemann et al. 2017 reported an incidence rate of 0.09 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.09 [0.09, 0.10]1 studyUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Vermaire et al. 2014 reported an incidence rate of 0.06 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.06 [0.06, 0.07]1 studyUngraded
Annual increment in dmft (primary dentition)
Per year of follow-up
Population: Children (primary dentition, d3), Western or comparable populations
In the primary dentition, the annual dmft increment ranged from -0.3 to 0.3 across 4 studies; values were inconsistent because of tooth exfoliation and could not be pooled (ungraded).
Source: Results 'Primary Dentition'; Table 2 · same question in other reviews
-0.3 to 0.34 studies · 1734 participantsUngraded
First dentine caries incidence rate per person-year at risk (D3)
Follow-up of at least 3 years
Peres et al. 2016 reported an incidence rate of 0.09 per person-year at risk.
Source: Figure 2 · same question in other reviews
Incidence rate per person-year at risk 0.09 [0.09, 0.09]1 studyUngraded

Longer follow-up vs Shorter follow-up

Population: Children and adolescents with permanent dentition
28 questions
OutcomeEffectEvidenceStatus / GRADE
Annual increment in DMFT (D3)
Per additional year of follow-up · Not adjusted
Not adjusted meta-regression beta was 0.18 per additional follow-up year.
Meta-regression beta per year of follow-up 0.18 [-0.04, 0.40]13 studies · 24753 participantsUngraded
Annual decline in percentage of caries-free participants (permanent dentition, D3)
Annual (studies with >=3 y follow-up) · Baseline caries experience: low
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For low baseline caries experience, the annual decline in caries-free participants ranged 4.3% to 10.2% (9 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
4.3% to 10.2%9 studies · 4811 participantsUngraded
Annual increment in DMFT (permanent dentition)
Per year of follow-up
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
In the permanent dentition, the annual DMFT increment ranged from 0.06 to 0.73 across 14 studies, and was higher where baseline caries experience was higher (descriptive range; ungraded).
Source: Results 'Permanent Dentition'; Table 2 · same question in other reviews
0.06 to 0.7314 studies · 25206 participantsUngraded
Annual increment in DMFT (D3)
Per additional year of follow-up · Adjusted for bitewings and age at baseline
Adjusted for bitewings and age at baseline meta-regression beta was 0.18 per additional follow-up year.
Meta-regression beta per year of follow-up 0.18 [0.02, 0.35]13 studies · 24753 participantsUngraded
Caries incidence rate per person-year at risk (D3)
Per additional year of follow-up · Adjusted for bitewings age at baseline and baseline caries experience
Adjusted for bitewings age at baseline and baseline caries experience meta-regression beta was 0.00 per additional follow-up year.
Meta-regression beta per year of follow-up 0.00 [-0.00, 0.01]15 studies · 10768 participantsUngraded
Caries incidence rate per person-year at risk (D3)
Per additional year of follow-up · Adjusted for groups 1-3 including decade and preventive intervention
Adjusted for groups 1-3 including decade and preventive intervention meta-regression beta was -0.00 per additional follow-up year.
Meta-regression beta per year of follow-up -0.00 [-0.02, 0.02]15 studies · 10768 participantsUngraded
Annual increment in DMFS (D3)
Per additional year of follow-up · Not adjusted
Not adjusted meta-regression beta was 0.43 per additional follow-up year.
Meta-regression beta per year of follow-up 0.43 [0.04, 0.83]22 studies · 11300 participantsUngraded
Caries incidence rate (first D3 lesion) per person-year at risk (permanent dentition)
Per person-year at risk
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
In the permanent dentition, the pooled caries incidence rate was 0.11 per person-year at risk (95% CI 0.09 to 0.13; random-effects meta-analysis of 15 studies), i.e., about 11 of every 100 caries-free persons develop dentine caries each year (ungraded).
Source: Results 'Meta-Analysis and Meta-Regression Analyses'; Table 3; Fig. 2 (forest plot) · same question in other reviews
Incidence rate (per person-year at risk) 0.11 [0.09, 0.13]15 studies · 10768 participantsUngraded
Annual increment in DMFS (D3)
Per additional year of follow-up · Adjusted for bitewings and age at baseline
Adjusted for bitewings and age at baseline meta-regression beta was 0.64 per additional follow-up year.
Meta-regression beta per year of follow-up 0.64 [0.31, 0.96]22 studies · 11300 participantsUngraded
Annual decline in percentage of caries-free participants (permanent dentition, D3)
Annual (studies with >=3 y follow-up)
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
In the permanent dentition, the annual decline in caries-free participants ranged from 0.8% to 10.2% across 18 studies, and was smaller where baseline caries experience was higher (descriptive range; ungraded).
Source: Results 'Permanent Dentition'; Table 2 · same question in other reviews
0.8% to 10.2%18 studies · 12017 participantsUngraded
Annual decline in percentage of caries-free participants (permanent dentition, D3)
Annual (studies with >=3 y follow-up) · Baseline caries experience: high
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For high baseline caries experience, the annual decline in caries-free participants ranged 0.8% to 2.2% (2 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.8% to 2.2%2 studies · 5029 participantsUngraded
Annual increment in DMFT (D3)
Per additional year of follow-up · Adjusted for bitewings age at baseline and baseline caries experience
Adjusted for bitewings age at baseline and baseline caries experience meta-regression beta was 0.23 per additional follow-up year.
Meta-regression beta per year of follow-up 0.23 [0.06, 0.40]13 studies · 24753 participantsUngraded
Annual increment in DMFS (D3)
Per additional year of follow-up · Adjusted for groups 1-4 including relevance of evidence and risk of bias
Adjusted for groups 1-4 including relevance of evidence and risk of bias meta-regression beta was 0.46 per additional follow-up year.
Meta-regression beta per year of follow-up 0.46 [0.08, 0.83]22 studies · 11300 participantsUngraded
Caries incidence rate per person-year at risk (D3)
Per additional year of follow-up · Adjusted for bitewings and age at baseline
Adjusted for bitewings and age at baseline meta-regression beta was 0.00 per additional follow-up year.
Meta-regression beta per year of follow-up 0.00 [-0.00, 0.01]15 studies · 10768 participantsUngraded
Annual increment in DMFS (D3)
Per additional year of follow-up · Adjusted for bitewings age at baseline and baseline caries experience
Adjusted for bitewings age at baseline and baseline caries experience meta-regression beta was 0.37 per additional follow-up year.
Meta-regression beta per year of follow-up 0.37 [0.04, 0.70]22 studies · 11300 participantsUngraded
Annual increment in DMFS (permanent dentition)
Per year of follow-up
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
In the permanent dentition, the annual DMFS increment ranged from 0.07 to 1.77 across 26 studies, and was higher where baseline caries experience was higher (descriptive range; ungraded).
Source: Results 'Permanent Dentition'; Table 2 · same question in other reviews
0.07 to 1.7726 studies · 22803 participantsUngraded
Caries incidence rate per person-year at risk (D3)
Per additional year of follow-up · Not adjusted
Not adjusted meta-regression beta was -0.00 per additional follow-up year.
Meta-regression beta per year of follow-up -0.00 [-0.01, 0.01]15 studies · 10768 participantsUngraded
Caries incidence rate per person-year at risk (D3)
Per additional year of follow-up · Adjusted for groups 1-4 including relevance of evidence and risk of bias
Adjusted for groups 1-4 including relevance of evidence and risk of bias meta-regression beta was -0.02 per additional follow-up year.
Meta-regression beta per year of follow-up -0.02 [-0.05, 0.01]15 studies · 10768 participantsUngraded
Annual increment in DMFT (permanent dentition)
Per year of follow-up · Baseline caries experience: high
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For high baseline caries experience, a single study reported an annual DMFT increment of 0.39 (1 study; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.391 study · 4380 participantsUngraded
Annual increment in DMFS (permanent dentition)
Per year of follow-up · Baseline caries experience: moderate
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For moderate baseline caries experience, the annual DMFS increment ranged 0.23 to 1.23 (13 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.23 to 1.2313 studies · 16473 participantsUngraded
Annual increment in DMFS (D3)
Per additional year of follow-up · Adjusted for groups 1-3 including decade and preventive intervention
Adjusted for groups 1-3 including decade and preventive intervention meta-regression beta was 0.36 per additional follow-up year.
Meta-regression beta per year of follow-up 0.36 [-0.02, 0.73]22 studies · 11300 participantsUngraded
Annual increment in DMFT (D3)
Per additional year of follow-up · Adjusted for groups 1-4 including relevance of evidence and risk of bias
Adjusted for groups 1-4 including relevance of evidence and risk of bias meta-regression beta was -0.04 per additional follow-up year.
Meta-regression beta per year of follow-up -0.04 [-0.34, 0.26]13 studies · 24753 participantsUngraded
Annual increment in DMFT (D3)
Per additional year of follow-up · Adjusted for groups 1-3 including decade and preventive intervention
Adjusted for groups 1-3 including decade and preventive intervention meta-regression beta was 0.07 per additional follow-up year.
Meta-regression beta per year of follow-up 0.07 [-0.24, 0.39]13 studies · 24753 participantsUngraded
Annual increment in DMFS (permanent dentition)
Per year of follow-up · Baseline caries experience: high
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For high baseline caries experience, the annual DMFS increment ranged 0.44 to 1.77 (5 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.44 to 1.775 studies · 2595 participantsUngraded
Annual decline in percentage of caries-free participants (permanent dentition, D3)
Annual (studies with >=3 y follow-up) · Baseline caries experience: moderate
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For moderate baseline caries experience, the annual decline in caries-free participants ranged 3.7% to 8.3% (4 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
3.7% to 8.3%4 studies · 928 participantsUngraded
Annual increment in DMFT (permanent dentition)
Per year of follow-up · Baseline caries experience: moderate
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For moderate baseline caries experience, the annual DMFT increment ranged 0.24 to 0.73 (6 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.24 to 0.736 studies · 16705 participantsUngraded
Annual increment in DMFT (permanent dentition)
Per year of follow-up · Baseline caries experience: low
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For low baseline caries experience, the annual DMFT increment ranged 0.06 to 0.34 (7 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.06 to 0.347 studies · 4121 participantsUngraded
Annual increment in DMFS (permanent dentition)
Per year of follow-up · Baseline caries experience: low
Population: Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations
For low baseline caries experience, the annual DMFS increment ranged 0.07 to 0.53 (8 studies; ungraded).
Source: Table 2 (baseline caries experience subgroups) · same question in other reviews
0.07 to 0.538 studies · 3735 participantsUngraded

Included primary studies 43

Open as a trial list
StudyAlso included byOutcomes it informs hereTrial PICOResults
Petersen et al. 2004
Effect of a school-based oral health education programme in Wuhan City, Peoples Republic of China.
PMID:15005471
1 other reviewnot statednot extracted yetnot extracted yet
Tai et al. 2009
Assessing the effectiveness of a school-based oral health promotion programme in Yichang City, China.
PMID:19624698
1 other reviewnot statednot extracted yetnot extracted yet
Alanen et al. 2000
Xylitol candies in caries prevention: results of a field study in Estonian children.
PMID:10830649
this review onlynot statednot extracted yetnot extracted yet
Basha et al. 2017
Caries Incidence Among Obese Adolescents: 
A 3-year Prospective Study.
PMID:28232976
this review onlynot statednot extracted yetnot extracted yet
Bruno-Ambrosius et al. 2005
Eating habits, smoking and toothbrushing in relation to dental caries: a 3-year study in Swedish female teenagers.
PMID:15854115
this review onlynot statednot extracted yetnot extracted yet
David et al. 2006
Caries increment and prediction from 12 to 18 years of age: a follow-up study.
PMID:17140525
this review onlynot statednot extracted yetnot extracted yet
Ekbäck et al. 2016
Reporting dental caries disease in longitudinal studies - a suggestion.
PMID:28853789
this review onlynot statednot extracted yetnot extracted yet
Forgie et al. 2000
A randomised controlled trial of the caries-preventive efficacy of a chlorhexidine-containing varnish in high-caries-risk adolescents.
PMID:11014911
this review onlynot statednot extracted yetnot extracted yet
Foster Page and Thomson 2012
Caries prevalence, severity, and 3-year increment, and their impact upon New Zealand adolescents' oral-health-related quality of life.
PMID:22506615
this review onlynot statednot extracted yetnot extracted yet
Hanachowicz 1984
Caries prevention using a 1.2% sodium monofluorophosphate dentifrice in an aluminium oxide trihydrate base.
PMID:6365424
this review onlynot statednot extracted yetnot extracted yet
Heidmann and Poulsen 1997
Comparative three-year caries protection from an aluminum-containing and a fluoride-containing toothpaste.
PMID:9118189
this review onlynot statednot extracted yetnot extracted yet
Heinemann et al. 2017
[Influence of Fissure Sealants on Dental Health of Elementary School Children in Weimar - A Longitudinal Observational Study under…
PMID:26630446
this review onlynot statednot extracted yetnot extracted yet
Heyduck et al. 2006
Effectiveness of sealants in adolescents with high and low caries experience.
PMID:16946604
this review onlynot statednot extracted yetnot extracted yet
Holmén et al. 2013
Tobacco use and caries risk among adolescents--a longitudinal study in Sweden.
PMID:23855639
this review onlynot statednot extracted yetnot extracted yet
Holt 1995
The pattern of caries in a group of 5-year-old children and in the same cohort at 9 years of age.
PMID:7648418
this review onlynot statednot extracted yetnot extracted yet
Isokangas et al. 1993
Long-term effect of xylitol chewing gum in the prevention of dental caries: a follow-up 5 years after termination of a prevention program.
PMID:8281565
this review onlynot statednot extracted yetnot extracted yet
Julihn et al. 2009
Maternal overweight and smoking: prenatal risk factors for caries development in offspring during the teenage period.
PMID:19856208
this review onlynot statednot extracted yetnot extracted yet
Kallestal 2005
The effect of five years' implementation of caries-preventive methods in Swedish high-risk adolescents.
PMID:15591730
this review onlynot statednot extracted yetnot extracted yet
Karjalainen et al. 1994
Caries development after substitution of supervised fluoride rinses and toothbrushings by unsupervised use of fluoride toothpaste.
PMID:7882656
this review onlynot statednot extracted yetnot extracted yet
Karjalainen et al. 2001
A prospective study on sucrose consumption, visible plaque and caries in children from 3 to 6 years of age.
PMID:11300173
this review onlynot statednot extracted yetnot extracted yet
Kruger et al. 1998
Dental caries and changes in dental anxiety in late adolescence.
PMID:9792129
this review onlynot statednot extracted yetnot extracted yet
Lenkkeri et al. 2012
The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized…
PMID:21951305
this review onlynot statednot extracted yetnot extracted yet
Li et al. 2017
Longitudinal Association between Obesity and Dental Caries in Adolescents.
PMID:28728812
this review onlynot statednot extracted yetnot extracted yet
Margolis et al. 1994
Distribution of primary tooth caries in first-grade children from two nonfluoridated US communities.
PMID:8058544
this review onlynot statednot extracted yetnot extracted yet
Masood et al. 2012
Assessment of dental caries predictors in 6-year-old school children - results from 5-year retrospective cohort study.
PMID:23158416
this review onlynot statednot extracted yetnot extracted yet
Morgan et al. 1998
The efficacy and effectiveness of a primary preventive dental programme in non-fluoridated areas of Victoria, Australia.
PMID:9973728
this review onlynot statednot extracted yetnot extracted yet
Peres et al. 2016
Sugar Consumption and Changes in Dental Caries from Childhood to Adolescence.
PMID:26758380
this review onlynot statednot extracted yetnot extracted yet
Pienihäkkinen et al. 2004
Assessment of caries risk in preschool children.
PMID:14767173
this review onlynot statednot extracted yetnot extracted yet
Poulsen 1987
Caries risk children in the Danish child dental service.
PMID:3671918
this review onlynot statednot extracted yetnot extracted yet
Ruiken et al. 1986
Longitudinal study of dental caries development in Dutch children aged 8-12 years.
PMID:3456876
this review onlynot statednot extracted yetnot extracted yet
Sanchez-Perez et al. 2010
Dental caries, tooth eruption timing and obesity: a longitudinal study in a group of Mexican schoolchildren.
PMID:19958253
this review onlynot statednot extracted yetnot extracted yet
Schmoeckel et al. 2015
Long-term caries development in schoolchildren and the role of educational status.
PMID:25646171
this review onlynot statednot extracted yetnot extracted yet
Skold et al. 1994
Four-year study of caries inhibition of intensive Duraphat application in 11-15-year-old children.
PMID:8143448
this review onlynot statednot extracted yetnot extracted yet
Skold et al. 2001
Caries incidence in adolescents with low caries prevalence after cessation of weekly fluoride rinsing.
PMID:11370752
this review onlynot statednot extracted yetnot extracted yet
Swedberg et al. 1997a
Caries extreme groups among adolescents, leaving organised dental care in Göteborg, Sweden.
PMID:9505334
this review onlynot statednot extracted yetnot extracted yet
Swedberg et al. 1997b
On longitudinal caries index data. A comparison study between cohort and cross-sectional attempts.
PMID:9472150
this review onlynot statednot extracted yetnot extracted yet
Tickle et al. 2017
A Randomized Controlled Trial of Caries Prevention in Dental Practice.
PMID:28375708
this review onlynot statednot extracted yetnot extracted yet
Truin and van 't Hof 2005
Professionally applied fluoride gel in low-caries 10.5-year-olds.
PMID:15840776
this review onlynot statednot extracted yetnot extracted yet
van Palenstein Helderman et al. 2001
The value of salivary bacterial counts as a supplement to past caries experience as caries predictor in children.
PMID:11695751
this review onlynot statednot extracted yetnot extracted yet
van Rijkom et al. 2004
Caries-inhibiting effect of professional fluoride gel application in low-caries children initially aged 4.5-6.5 years.
PMID:14767168
this review onlynot statednot extracted yetnot extracted yet
Vermaire et al. 2014
A three-year randomized controlled trial in 6-year-old children on caries-preventive strategies in a general dental practice in the…
PMID:24924292
this review onlynot statednot extracted yetnot extracted yet
Virtanen 2001
Changes and trends in attack distributions and progression of dental caries in three age cohorts in Finland.
PMID:12036266
this review onlynot statednot extracted yetnot extracted yet
Zimmer et al. 1999
Caries prevention with fluoride varnish in a socially deprived community.
PMID:10226719
this review onlynot statednot extracted yetnot extracted yet

Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).