What do systematic reviews say?

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (1 month) · Mixed TMD
  MD -1.42 [-15.78, 12.94]
  2 studies · 73 participants
  GRADE not reported

Inhaled corticosteroids vs placebo

• Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 2507 participants
  Moderate

Summary of findings – strontium ranelate vs placebo

• Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

Autologous blood or PRP vs placebo at 3 months' follow‐up

• Autologous blood and platelet‐rich plasma injection therapy for lateral elbow pain 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Trazodone vs placebo

The review found no eligible studies for this question.

• Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

mHealth education intervention vs usual care

• mHealth education interventions in heart failure 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 942 participants
  Very low

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
  1 study · 26 participants
  Very low

Inhaled corticosteroids vs placebo

• Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Case management vs usual care

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1595 participants
  Very low

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  Reported narratively by 2 studies (Wang 2012: SF-36 and SAS - significant reduction in SF-36 bodily pain at 30 days vs baseline, no significant between-group differences; Minor 2009: STAI and PANAS - no significant…
  2 studies
  GRADE not reported

NSAID (systemic) vs paracetamol

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  The study did not report this outcome.
  0 studies
  No studies found

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  The study did not report this outcome.
  0 studies
  No studies found

Active music therapy vs receptive music therapy

• Music therapy for depression 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 9 participants
  Very low

Individual TF‐CBT vs EMDR

The review found no eligible studies for this question.

• Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

EMDR vs inactive control (usual care care, attention control, waitlist)

The review found no eligible studies for this question.

• Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Online support groups for women with breast cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 78 participants
  Low

Intervention not reported

• Braces and orthoses for treating osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 117 participants
  Low

Chronic MND: Qigong Stretch/ROM + Endurance Training + Dynamic Stabilization + Cognitive (mindfulness & emotional balance) vs WAIT LIST

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 148 participants
  Moderate