Cochrane · systematic review · CD002991
Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease
Yang, IA, Ferry, OR, Clarke, MS, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ ICS compared to placebo for adults with stable chronic obstructive pulmonary disease in studies of greater than six months? duration
Population: adults with stable chronic obstructive pulmonary disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation rate (exacerbations per participant per year) Summary of findings table ‐ ICS vs placebo | no estimate extracted | 5 studies · 10316 participants | Moderate Downgraded: imprecision |
Quality of life (mean change in SGRQ score) Summary of findings table ‐ ICS vs placebo | no estimate extracted | 5 studies · 2507 participants | Moderate Downgraded: imprecision |
Change in postbronchodilator FEV1 (mL/year) Summary of findings table ‐ ICS vs placebo | no estimate extracted | 6 studies · 12502 participants | Moderate Downgraded: imprecision |
Mortality Summary of findings table ‐ ICS vs placebo | OR 0.94 [0.84, 1.07] | 10 studies · 16636 participants | Moderate Downgraded: imprecision |
Pneumonia Summary of findings table ‐ ICS vs placebo | OR 1.38 [1.02, 1.88] | 9 studies · 14831 participants | Low Downgraded: imprecision, inconsistency |
Oropharyngeal candidiasis Summary of findings table ‐ ICS vs placebo | OR 2.66 [1.91, 3.68] | 7 studies · 5547 participants | Moderate Downgraded: imprecision |