Cochrane · systematic review · CD010429
Treatment for osteoporosis in people with beta‐thalassaemia
Bhardwaj, A, Swe, KM, Sinha, NK · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
35
current version
GRADE rated
12
No studies
23
Included studies
NR
No studies 23 · 65.7%Ungraded 0 · 0%Very low 6 · 17.1%Low 3 · 8.6%Moderate 3 · 8.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings – bisphosphonates versus placebo or no treatment
Population: adults with β‐thalassaemia and osteoporosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BMD Z score (total hip/femoral neck) Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | NR | No studies |
BMD Z score (lumbar spine) Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | NR | No studies |
BMD Z score (wrist) Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | NR | No studies |
Incidence of fractures Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | 1 study · 118 participants | Moderate Downgraded: imprecision |
Mobility Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | NR | No studies |
Quality of life (change in mean back pain) Summary of findings – bisphosphonates vs placebo or no treatment | no estimate extracted | 1 study · 118 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects of treatment Summary of findings – bisphosphonates vs placebo or no treatment | OR 15 | 2 studies · 143 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings – different doses of bisphosphonates compared
Population: people with β‐thalassaemia and osteoporosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BMD Z score (total hip/femoral neck) | no estimate extracted | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
BMD Z score (lumbar spine) | MD 0.43 [0.1, 0.76] | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
BMD Z score (wrist) Â | no estimate extracted | NR | No studies |
Incidence of fractures | no estimate extracted | NR | No studies |
Mobility | no estimate extracted | NR | No studies |
Quality of life | no estimate extracted | NR | No studies |
Adverse effects of treatment | no estimate extracted | NR | No studies |
Summary of findings – zinc versus placebo
Population: children and adults with β‐thalassaemia major and low bone mass
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BMD Z score (total hip/femoral neck) Summary of findings – zinc vs placebo | MD 0.15 [0.11, 0.19] | 1 study · 37 participants | Moderate Downgraded: imprecision |
BMD Z score (lumbar spine) Summary of findings – zinc vs placebo | MD 0.15 [0.1, 0.2] | 1 study · 37 participants | Moderate Downgraded: imprecision |
BMD Z score (wrist) Summary of findings – zinc vs placebo | no estimate extracted | NR | No studies |
Incidence of fractures Summary of findings – zinc vs placebo | no estimate extracted | NR | No studies |
Mobility Summary of findings – zinc vs placebo | no estimate extracted | NR | No studies |
Quality of life Summary of findings – zinc vs placebo | no estimate extracted | NR | No studies |
Adverse effects of treatment Summary of findings – zinc vs placebo | no estimate extracted | NR | No studies |
Summary of findings – denosumab versus placebo
Population: adults with β‐thalassaemia and low bone mass
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BMD Z score (total hip/femoral neck) Summary of findings – denosumab vs placebo | MD 0.05 | 1 study · 63 participants | Low Downgraded: imprecision, indirectness |
BMD Z score (lumbar spine) Summary of findings – denosumab vs placebo | no estimate extracted | 1 study · 63 participants | Low Downgraded: imprecision, indirectness |
BMD Z score (wrist) Summary of findings – denosumab vs placebo | no estimate extracted | 1 study · 63 participants | Low Downgraded: imprecision, indirectness |
Incidence of fractures Summary of findings – denosumab vs placebo | no estimate extracted | NR | No studies |
Mobility Summary of findings – denosumab vs placebo | no estimate extracted | NR | No studies |
Quality of life Summary of findings – denosumab vs placebo | no estimate extracted | NR | No studies |
Adverse effects of treatment Summary of findings – denosumab vs placebo | no estimate extracted | NR | No studies |
Summary of findings – strontium ranelate versus placebo
Population: women with low bone mass and β‐thalassaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BMD Z score (total hip/femoral neck) Summary of findings – strontium ranelate vs placebo | no estimate extracted | NR | No studies |
BMD Z score (lumbar spine) Summary of findings – strontium ranelate vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
BMD Z score (wrist) Summary of findings – strontium ranelate vs placebo | no estimate extracted | NR | No studies |
Incidence of fractures Summary of findings – strontium ranelate vs placebo | no estimate extracted | NR | No studies |
Mobility Summary of findings – strontium ranelate vs placebo | no estimate extracted | NR | No studies |
Quality of life (back pain VAS score in cm) Summary of findings – strontium ranelate vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects of treatment Summary of findings – strontium ranelate vs placebo | no estimate extracted | NR | No studies |