Cochrane · systematic review · CD001915
Inhaled corticosteroids for cystic fibrosis
Balfour-Lynn, IM, Welch, K, Smith, S · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: inhaled corticosteroids compared with placebo for cystic fibrosis
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung function: FEV1 % predicted (change from baseline) Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 3 studies · 250 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Lung function: FVC % predicted (change from baseline) Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 3 studies · 250 participants | Low Downgraded: risk of bias, imprecision, publication bias |
BHR: change in PC20 values Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 3 studies · 100 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Improvement in exercise tolerance Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Respiratory exacerbations: number of days on intravenous antibiotics for respiratory exacerbations Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 17 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Quality of life: change in well‐being score Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 23 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse effects Summary of findings: inhaled corticosteroids vs placebo | no estimate extracted | 5 studies · 295 participants | Low Downgraded: risk of bias, imprecision, publication bias |