Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Adalimumab vs placebo

Withdrawals due to adverse events · Participants with Crohn's disease in remission

Adalimumab probably leads to lower withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Short‐term serious adverse events · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Withdrawals due to adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF discontinuation showed no clear difference in withdrawals due to adverse events compared with anti‐TNF continuation (moderate certainty).

1 finding from 1 review

Anti‐TNF dose reduction vs anti‐TNF continuation

Withdrawals due to adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF dose reduction showed no clear difference in withdrawals due to adverse events compared with anti‐TNF continuation (low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in withdrawals due to adverse events (low certainty).

1 finding from 1 review

Valproate vs placebo

Serious adverse events by 6 weeks · people with agitation in dementia

It is very uncertain whether valproate preparations changes serious adverse events by 6 weeks compared with placebo (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Adverse events at up to 2 months' · women with PMS

It is very uncertain whether acupuncture changes adverse events at up to 2 months' compared with sham (very low certainty).

1 finding from 1 review