Cochrane · systematic review · CD005984
Enteral nutrition for maintenance of remission in Crohn's disease
Akobeng, AK, Zhang, D, Gordon, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
7
No studies
17
Included studies
NR
No studies 17 · 60.7%Ungraded 4 · 14.3%Very low 3 · 10.7%Low 4 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Elemental formula supplements compared to polymeric formula supplements for maintenance of remission in Crohn's disease
Population: Participants with Crohn's disease in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse Elemental formula supplements vs polymeric formula supplements | RR 1.01 [0.56, 1.84] | 1 study · 33 participants | Very low Downgraded: risk of bias |
Change in weight Elemental formula supplements vs polymeric formula supplements | no estimate extracted | NR | No studies |
Change in height Elemental formula supplements vs polymeric formula supplements | no estimate extracted | NR | No studies |
Change in quality of life Elemental formula supplements vs polymeric formula supplements | no estimate extracted | NR | No studies |
Adverse events Elemental formula supplements vs polymeric formula supplements | no estimate extracted | NR | No studies |
Serious adverse events Elemental formula supplements vs polymeric formula supplements | no estimate extracted | NR | No studies |
Withdrawals due to adverse events Elemental formula supplements vs polymeric formula supplements | RR 9.75 [0.59, 159.93] | 1 study · 33 participants | Low Downgraded: risk of bias, imprecision |
Elemental formula supplements compared to no supplementation for maintenance of remission in Crohn's disease
Population: Participants with Crohn's disease in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse Elemental formula supplements vs no supplementation | RR 0.54 [0.3, 0.99] | 1 study · 51 participants | Very low Downgraded: risk of bias |
Change in weight (kg) Elemental formula supplements vs no supplementation | no estimate extracted | NR | No studies |
Change in height Elemental formula supplements vs no supplementation | no estimate extracted | NR | No studies |
Change in quality of life Elemental formula supplements vs no supplementation | no estimate extracted | NR | No studies |
Adverse events Elemental formula supplements vs no supplementation | no estimate extracted | 1 study · 51 participants | Ungraded |
Serious adverse events Elemental formula supplements vs no supplementation | no estimate extracted | 1 study · 51 participants | Ungraded |
Withdrawal due to adverse events Elemental formula supplements vs no supplementation | no estimate extracted | 1 study · 51 participants | Ungraded |
Enteral nutrition compared to 6‐MP for maintenance of remission in Crohn's disease
Population: Participants with Crohn's disease in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse Enteral nutrition vs 6‐MP | RR 1.61 [0.73, 3.53] | 1 study · 62 participants | Very low Downgraded: risk of bias |
Change in weight Enteral nutrition vs 6‐MP | no estimate extracted | NR | No studies |
Change in height Enteral nutrition vs 6‐MP | no estimate extracted | NR | No studies |
Change in quality of life Enteral nutrition vs 6‐MP | no estimate extracted | NR | No studies |
Adverse events Enteral nutrition vs 6‐MP | RR 0.23 [0.03, 1.98] | 1 study · 62 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events Enteral nutrition vs 6‐MP | no estimate extracted | 1 study · 62 participants | Ungraded |
Withdrawal due to adverse events Enteral nutrition vs 6‐MP | no estimate extracted | NR | No studies |
Enteral nutrition compared to mesalamine for maintenance of remission in Crohn's disease
Population: Participants with Crohn's disease in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse Enteral nutrition vs mesalamine | RR 0.76 [0.49, 1.19] | 1 study · 83 participants | Low Downgraded: risk of bias |
Change in weight (kg) Enteral nutrition vs mesalamine | no estimate extracted | 1 study · 66 participants | Low Downgraded: risk of bias, imprecision |
Change in height Enteral nutrition vs mesalamine | no estimate extracted | NR | No studies |
Change in quality of life Enteral nutrition vs mesalamine | no estimate extracted | NR | No studies |
Adverse events Enteral nutrition vs mesalamine | no estimate extracted | NR | No studies |
Serious adverse events Enteral nutrition vs mesalamine | no estimate extracted | NR | No studies |
Withdrawal due to adverse events Enteral nutrition vs mesalamine | no estimate extracted | NR | No studies |