Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Polycaprolactone Scaffolds for BONE Regeneration in Animal Models of Cranial Defects: A Systematic Review and Meta-Analysis. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Magnesium-containing composite hydrogel scaffolds with immunomodulatory and osteogenic dual effects enhance bone defect repair via CD4+ T cells… S. Liu 2026 · Liu Shubo, Chen Qinghua, et al. · Journal of Magnesium and Alloys DOI:10.1016/j.jma.2025.07.020 | 2026 | 1 | 1 | not extracted yet |
| Immunomodulatory 3D-printed hydroxyapatite/tricalcium phosphate/polycaprolactone scaffolds promote bone regeneration via macrophage polarization Tang 2026 · Tang Hao, Zhao Guangquan, et al. · International Journal of Bioprinting DOI:10.36922/ijb026060049 | 2026 | 1 | 3 | not extracted yet |
| Manganese-doped oleic acid functionalized whitlockite/polycaprolactone nanocomposite scaffolds enhance bone regeneration through improved… X. Liu 2025 · Liu Xiaofan, Liu Yang, et al. · Chemical Engineering Journal DOI:10.1016/j.cej.2025.164681 | 2025 | 1 | 2 | not extracted yet |
| An electrospun membrane incorporating lipocalin 2-enhanced exosomes effectively facilitated the repair of critical bone defects Lv 2025 · Lv Nanning, Li Hongye, et al. · International Journal of Biological Macromolecules DOI:10.1016/j.ijbiomac.2025.146674 | 2025 | 1 | 2 | not extracted yet |
| Silver nanoparticle-assembled guided bone regeneration membranes showcase dual functions: Initial bacterial elimination and subsequent immune… Guo 2025 · Guo Yu, Li Xin, et al. · Materials & Design DOI:10.1016/j.matdes.2025.113882 | 2025 | 1 | 2 | not extracted yet |
| Investigation and Characterization of Gold Nanoparticle-Loaded Poly(ε-caprolactone) Electrospun Nanofibrous Scaffolds with a Polydopamine Coating… Zhao 2025 · Zhao Hongling, Miao Guohou, et al. · ACS Biomaterials Science & Engineering DOI:10.1021/acsbiomaterials.5c00682 | 2025 | 1 | 2 | not extracted yet |
| Three-dimensional-printed hydroxyapatite/nanoclay/polycaprolactone composite scaffold for immunomodulation and bone defect repair X. Li 2025 · Li Xiang, Wen Zhenyu, et al. · International Journal of Bioprinting DOI:10.36922/ijb025170162 | 2025 | 1 | 3 | not extracted yet |
| Investigation and Characterization of Gold Nanoparticle-Loaded Poly(ε-caprolactone) Electrospun Nanofibrous Scaffolds with a Polydopamine Coating… Zhao 2025 · Zhao Hongling, Miao Guohou, et al. · ACS biomaterials science & engineering PMID:40571647 | 2025 | 1 | 1 | not extracted yet |
| An electrospun membrane incorporating lipocalin 2-enhanced exosomes effectively facilitated the repair of critical bone defects. Lv 2025 · Lv Nanning, Li Hongye, et al. · International journal of biological macromolecules PMID:40780325 | 2025 | 1 | 1 | not extracted yet |
| An osteoimmunomodulatory Ca2+/Zn2+-doped scaffold promotes M2 macrophage polarization via the src-mediated chemoking signaling pathway to enhance… K. Wang 2024 · Wang Kai, Jiang Kai, et al. · Composites Part B: Engineering DOI:10.1016/j.compositesb.2024.111653 | 2024 | 1 | 2 | not extracted yet |
| Evaluation of new bone formation in critical-sized rat calvarial defect using 3D printed polycaprolactone/tragacanth gum-bioactive glass composite… Janmohammadi 2024 · Janmohammadi Mahsa, Doostmohammadi Nesa, et al. · International Journal of Biological Macromolecules DOI:10.1016/j.ijbiomac.2024.132361 | 2024 | 1 | 2 | not extracted yet |
| Decellularized extracellular matrix coupled with polycaprolactone/laponite to construct a biomimetic barrier membrane for bone defect repair M. He 2024 · He Mengjiao, Li Lisheng, et al. · International Journal of Biological Macromolecules DOI:10.1016/j.ijbiomac.2024.133775 | 2024 | 1 | 1 | not extracted yet |
| A Biomimetic Fibrous Composite Scaffold with Nanotopography-Regulated Mineralization for Bone Defect Repair Jiang 2024 · Jiang Kai, Wang Kai, et al. · Biomacromolecules DOI:10.1021/acs.biomac.4c00378 | 2024 | 1 | 2 | not extracted yet |
| Dual Mg-Reinforced PCL Membrane with a Janus Structure for Vascularized Bone Regeneration and Bacterial Elimination. Wang 2024 · Wang Xianli, Shen Peiqi, et al. · ACS biomaterials science & engineering PMID:38065085 | 2024 | 1 | 1 | not extracted yet |
| Biomimetic Hydroxyapatite on 3D-Printed Nanoattapulgite/Polycaprolactone Scaffolds for Bone Regeneration of Rat Cranium Defects. Dai 2024 · Dai Ting, Wu Xiaoyu, et al. · ACS biomaterials science & engineering PMID:38146624 | 2024 | 1 | 1 | not extracted yet |
| A Biomimetic Fibrous Composite Scaffold with Nanotopography-Regulated Mineralization for Bone Defect Repair. Jiang 2024 · Jiang Kai, Wang Kai, et al. · Biomacromolecules PMID:38743836 | 2024 | 1 | 1 | not extracted yet |
| Evaluation of new bone formation in critical-sized rat calvarial defect using 3D printed polycaprolactone/tragacanth gum-bioactive glass composite… Janmohammadi 2024 · Janmohammadi Mahsa, Doostmohammadi Nesa, et al. · International journal of biological macromolecules PMID:38750857 | 2024 | 1 | 1 | not extracted yet |
| Decellularized extracellular matrix coupled with polycaprolactone/laponite to construct a biomimetic barrier membrane for bone defect repair. He 2024 · He Mengjiao, Li Lisheng, et al. · International journal of biological macromolecules PMID:38986979 | 2024 | 1 | 1 | not extracted yet |
| Augmented Repair and Regeneration of Critical Size Rabbit Calvaria Defects with 3D Printed Silk Fibroin Microfibers Reinforced PCL Composite Scaffolds Bojedla 2023 · Bojedla Sri Sai Ramya, Kattimani Vivekananda, et al. · Biomedical Materials & Devices DOI:10.1007/s44174-023-00072-1 | 2023 | 1 | 3 | not extracted yet |
| Biomimetic Hydroxyapatite on 3D-Printed Nanoattapulgite/Polycaprolactone Scaffolds for Bone Regeneration of Rat Cranium Defects Dai 2024 · Dai Ting, Wu Xiaoyu, et al. · ACS Biomaterials Science & Engineering DOI:10.1021/acsbiomaterials.3c00871 | 2023 | 1 | 2 | not extracted yet |
| Dual Mg-Reinforced PCL Membrane with a Janus Structure for Vascularized Bone Regeneration and Bacterial Elimination X. Wang 2024 · Wang Xianli, Shen Peiqi, et al. · ACS Biomaterials Science & Engineering DOI:10.1021/acsbiomaterials.3c01360 | 2023 | 1 | 2 | not extracted yet |
| 3D bioprinted autologous bone particle scaffolds for cranioplasty promote bone regeneration with both implanted and native BMSCs Huan 2023 · Huan Yu, Zhou Dezhi, et al. · Biofabrication DOI:10.1088/1758-5090/acbe21 | 2023 | 1 | 1 | not extracted yet |
| Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated… X. Xu 2023 · Xu Xiongcheng, Chen Ziqin, et al. · Journal of Nanobiotechnology DOI:10.1186/s12951-023-01982-4 | 2023 | 1 | 1 | not extracted yet |
| ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds B. Wang 2023 · Wang Bingqian, Zeng Yuyang, et al. · Journal of Nanobiotechnology DOI:10.1186/s12951-023-02007-w | 2023 | 1 | 2 | not extracted yet |
| Electrospun polycaprolactone incorporated with fluorapatite nanoparticles composite scaffolds enhance healing of experimental calvarial defect on rats S. He 2023 · He Shasha, Hu Qihang, et al. · Annals of Translational Medicine DOI:10.21037/atm-22-4865 | 2023 | 1 | 3 | not extracted yet |
| 3D bioprinted autologous bone particle scaffolds for cranioplasty promote bone regeneration with both implanted and native BMSCs. Huan 2023 · Huan Yu, Zhou Dezhi, et al. · Biofabrication PMID:36812580 | 2023 | 1 | 1 | not extracted yet |
| Electrospun polycaprolactone incorporated with fluorapatite nanoparticles composite scaffolds enhance healing of experimental calvarial defect on… He 2023 · He Shasha, Hu Qihang, et al. · Annals of translational medicine PMID:37404984 | 2023 | 1 | 1 | not extracted yet |
| Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated… Xu 2023 · Xu Xiongcheng, Chen Ziqin, et al. · Journal of nanobiotechnology PMID:37443072 | 2023 | 1 | 1 | not extracted yet |
| ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds. Wang 2023 · Wang Bingqian, Zeng Yuyang, et al. · Journal of nanobiotechnology PMID:37563652 | 2023 | 1 | 1 | not extracted yet |
| Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration de Souza Araujo 2022 · de Souza Araújo Isaac J., Ferreira Jessica A., et al. · Dental Materials DOI:10.1016/j.dental.2022.09.011 | 2022 | 1 | 2 | not extracted yet |
| Attapulgite-doped electrospun PCL scaffolds for enhanced bone regeneration in rat cranium defects Dai 2022 · Dai Ting, Ma Jiayi, et al. · Biomaterials Advances DOI:10.1016/j.msec.2022.112656 | 2022 | 1 | 1 | not extracted yet |
| Stem Cell-Seeded 3D-Printed Scaffolds Combined with Self-Assembling Peptides for Bone Defect Repair H. Xu 2022 · Xu Haixia, Wang Chengqiang, et al. · Tissue Engineering Part A DOI:10.1089/ten.tea.2021.0055 | 2022 | 1 | 1 | not extracted yet |
| Nanotopographical 3D-Printed Poly(ε-caprolactone) Scaffolds Enhance Proliferation and Osteogenic Differentiation of Urine-Derived Stem Cells for… Xing 2022 · Xing Fei, Yin Hua-Mo, et al. · Pharmaceutics DOI:10.3390/pharmaceutics14071437 | 2022 | 1 | 2 | not extracted yet |
| Stem Cell-Seeded 3D-Printed Scaffolds Combined with Self-Assembling Peptides for Bone Defect Repair. Xu 2022 · Xu Haixia, Wang Chengqiang, et al. · Tissue engineering. Part A PMID:34157886 | 2022 | 1 | 1 | not extracted yet |
| Attapulgite-doped electrospun PCL scaffolds for enhanced bone regeneration in rat cranium defects. Dai 2022 · Dai Ting, Ma Jiayi, et al. · Biomaterials advances PMID:35034813 | 2022 | 1 | 1 | not extracted yet |
| Nanotopographical 3D-Printed Poly(ε-caprolactone) Scaffolds Enhance Proliferation and Osteogenic Differentiation of Urine-Derived Stem Cells for… Xing 2022 · Xing Fei, Yin Hua-Mo, et al. · Pharmaceutics PMID:35890332 | 2022 | 1 | 1 | not extracted yet |
| Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. de Souza Araújo 2022 · de Souza Araújo Isaac J, Ferreira Jessica A, et al. · Dental materials : official publication of the Academy of Dental Materials PMID:36180310 | 2022 | 1 | 1 | not extracted yet |
| BMP-6 carrying metal organic framework-embedded in bioresorbable electrospun fibers for enhanced bone regeneration Toprak 2021 · Toprak Özge, Topuz Berna, et al. · Materials Science and Engineering: C DOI:10.1016/j.msec.2020.111738 | 2021 | 1 | 1 | not extracted yet |
| Boosting osteogenic potential and bone regeneration by co-cultured cell derived extracellular matrix incorporated porous electrospun scaffold Padalhin 2021 · Padalhin Andrew, Ventura Reiza, et al. · Journal of Biomaterials Science, Polymer Edition DOI:10.1080/09205063.2020.1869879 | 2021 | 1 | 2 | not extracted yet |
| Biomimetic three-layered membranes comprising (poly)-ε-caprolactone, collagen and mineralized collagen for guided bone regeneration Wu 2021 · Wu Jingjing, Yao Mengyu, et al. · Regenerative Biomaterials DOI:10.1093/rb/rbab065 | 2021 | 1 | 2 | not extracted yet |
| Boosting osteogenic potential and bone regeneration by co-cultured cell derived extracellular matrix incorporated porous electrospun scaffold. Padalhin 2021 · Padalhin Andrew, Ventura Reiza, et al. · Journal of biomaterials science. Polymer edition PMID:33375905 | 2021 | 1 | 1 | not extracted yet |
| BMP-6 carrying metal organic framework-embedded in bioresorbable electrospun fibers for enhanced bone regeneration. Toprak 2021 · Toprak Özge, Topuz Berna, et al. · Materials science & engineering. C, Materials for biological applications PMID:33545881 | 2021 | 1 | 1 | not extracted yet |
| Biomimetic three-layered membranes comprising (poly)-ε-caprolactone, collagen and mineralized collagen for guided bone regeneration. Wu 2021 · Wu Jingjing, Yao Mengyu, et al. · Regenerative biomaterials PMID:34881047 | 2021 | 1 | 1 | not extracted yet |
| Osteogenic growth peptide-loaded 3D-printed PCL scaffolds for the promotion of osteogenesis through the ERK pathway Q. Wang 2020 · Wang Qing, Yang Xiaojie, et al. · Materials & Design DOI:10.1016/j.matdes.2020.108811 | 2020 | 1 | 2 | not extracted yet |
| 3D printing of metal–organic framework incorporated porous scaffolds to promote osteogenic differentiation and bone regeneration Zhong 2020 · Zhong Linna, Chen Junyu, et al. · Nanoscale DOI:10.1039/d0nr06297a | 2020 | 1 | 1 | not extracted yet |
| 3D printing of metal-organic framework incorporated porous scaffolds to promote osteogenic differentiation and bone regeneration. Zhong 2020 · Zhong Linna, Chen Junyu, et al. · Nanoscale PMID:33305769 | 2020 | 1 | 1 | not extracted yet |
| Engineered 3D printed poly(ɛ-caprolactone)/graphene scaffolds for bone tissue engineering W. Wang 2019 · Wang Weiguang, Junior José Roberto Passarini, et al. · Materials Science and Engineering: C DOI:10.1016/j.msec.2019.03.047 | 2019 | 1 | 2 | not extracted yet |
| Accelerating Bone Healing by Decorating BMP-2 on Porous Composite Scaffolds X. Li 2019 · Li Xiang, Yin Hua-Mo, et al. · ACS Applied Bio Materials DOI:10.1021/acsabm.9b00761 | 2019 | 1 | 2 | not extracted yet |
| Bioinspired and osteopromotive polydopamine nanoparticle-incorporated fibrous membranes for robust bone regeneration Deng 2019 · Deng Yi, Yang Wei-Zhong, et al. · NPG Asia Materials DOI:10.1038/s41427-019-0139-5 | 2019 | 1 | 2 | not extracted yet |
| Engineered 3D printed poly(ɛ-caprolactone)/graphene scaffolds for bone tissue engineering. Wang 2019 · Wang Weiguang, Junior José Roberto Passarini, et al. · Materials science & engineering. C, Materials for biological applications PMID:30948113 | 2019 | 1 | 1 | not extracted yet |