Primary study · included by 1 review

3D bioprinted autologous bone particle scaffolds for cranioplasty promote bone regeneration with both implanted and native BMSCs

Huan 2023 · Huan Yu, Zhou Dezhi, Wu Xiuquan, et al. · Biofabrication · 2023

Included by

Polycaprolactone Scaffolds for BONE Regeneration in Animal Models of Cranial Defects: A Systematic Review and Meta-Analysis

Non-Cochrane · intervention · 2026 · cited as Huan 2023 · Figures 2-4; Table 4; reference [17]

Outcome this study informs	Pooled effect	Evidence	Certainty
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	QM = 0.163, df = 3, p = 0.983, R2 = 0%	16 studies	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	QM = 0.01, df = 1, p = 0.922, R2 = 0%	16 studies	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	Meta-regression beta (difference in MD, %) -0.646 [-15.869, 14.577]	16 studies	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	QM = 0.099, df = 1, p = 0.753, R2 = 0%	16 studies	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	MD 2.22 [-1.36, 5.8]	15 studies · 122 participants	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	Meta-regression beta (difference in MD, %) -0.556 [-15.803, 14.691]	16 studies	GRADE not reported
Bone regeneration (BV/TV, %) after 2 months (late stage, 3 months) Polycaprolactone (PCL)-only scaffold vs Empty defect · After 2 months (late; 3 months)	Meta-regression beta (difference in MD, %) 1.527 [-6.989, 10.044]	16 studies	GRADE not reported

1 including review in total.