Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Evaluating the Efficacy of Resveratrol-Containing Mouthwash as an Adjunct Treatment for Periodontitis: A Randomized Clinical Trial. Mohammed et al., 2025 · Mohammed Sura A, Akram Hadeel Mazin · European journal of dentistry PMID:39251207 | 2025 | 2 | 4 | not extracted yet |
| Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical… Nikniaz et al., 2023 · Nikniaz Shabnam, Vaziri Farzane, et al. · BMC oral health PMID:36973728 | 2023 | 2 | 4 | not extracted yet |
| Evaluating the Efficacy of Resveratrol-Containing Mouthwash as an Adjunct Treatment for Periodontitis: A Randomized Clinical Trial Mohammed 2025 · Mohammed Sura A., Akram Hadeel Mazin · European Journal of Dentistry DOI:10.1055/s-0044-1788686 | 2024 | 1 | none stated | not extracted yet |
| Evaluation of the Effect of Topically Applied Resveratrol Gel as Adjunctive Treatment for Periodontitis Hussein 2024 · Hussein Mahmoud Hassan, Badr Bahaa Mohammed, et al. · European Journal of General Dentistry DOI:10.1055/s-0044-1795084 | 2024 | 1 | 2 | not extracted yet |
| Facile engineering of resveratrol nanoparticles loaded with 20(S)-protopanaxadiol for the treatment of periodontitis by regulating the macrophage… Huangfu 2023 · Huangfu Huimin, Du Shulin, et al. · Nanoscale DOI:10.1039/d2nr06452a | 2023 | 1 | none stated | not extracted yet |
| Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical… Nikniaz 2023 · Nikniaz Shabnam, Vaziri Farzane, et al. · BMC Oral Health DOI:10.1186/s12903-023-02877-4 | 2023 | 1 | none stated | not extracted yet |
| Facile engineering of resveratrol nanoparticles loaded with 20(S)-protopanaxadiol for the treatment of periodontitis by regulating the macrophage… Huangfu 2023 · Huangfu Huimin, Du Shulin, et al. · Nanoscale PMID:37060139 | 2023 | 1 | none stated | not extracted yet |
| Gingivitis Effectiveness of Emulgel Containing 2% Resveratrol in Orthodontic Patients: An 8-Week Randomized Clinical Trial Golshah 2021 · Golshah Amin, Mirzaeei Shahla, et al. · International Journal of Dentistry DOI:10.1155/2021/6615900 | 2021 | 1 | none stated | not extracted yet |
| Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy Shi 2021 · Shi Junyu, Zhang Yi, et al. · Journal of Nanobiotechnology DOI:10.1186/s12951-021-01175-x | 2021 | 1 | none stated | not extracted yet |
| Gingivitis Effectiveness of Emulgel Containing 2% Resveratrol in Orthodontic Patients: An 8-Week Randomized Clinical Trial. Golshah 2021 · Golshah Amin, Mirzaeei Shahla, et al. · International journal of dentistry PMID:33859693 | 2021 | 1 | 1 | not extracted yet |
| An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach. Berta 2021 · Berta Giovanni Nicolao, Romano Federica, et al. · Materials (Basel, Switzerland) PMID:34300720 | 2021 | 1 | 2 | not extracted yet |
| Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy. Shi 2021 · Shi Junyu, Zhang Yi, et al. · Journal of nanobiotechnology PMID:34930286 | 2021 | 1 | 7 | not extracted yet |
| Resveratrol derivative‐rich melinjo seed extract induces healing in a murine model of established periodontitis Ikeda 2018 · Ikeda Eri, Ikeda Yuichi, et al. · Journal of Periodontology DOI:10.1002/jper.17-0352 | 2018 | 1 | none stated | not extracted yet |
| Resveratrol derivative-rich melinjo seed extract induces healing in a murine model of established periodontitis. Ikeda 2018 · Ikeda Eri, Ikeda Yuichi, et al. · Journal of periodontology PMID:29856488 | 2018 | 1 | 3 | not extracted yet |
| Systemic treatment with resveratrol and/or curcumin reduces the progression of experimental periodontitis in rats. Correa 2017 · Corrêa M G, Pires P R, et al. · Journal of periodontal research PMID:27135637 | 2017 | 1 | 2 | not extracted yet |
| Proliferative and Anti-Inflammatory Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts: A View to the Future. Shahidi 2017 · Shahidi Minoo, Vaziri Farzaneh, et al. · Journal of dentistry (Tehran, Iran) PMID:29285030 | 2017 | 1 | 2 | not extracted yet |
| Systemic treatment with resveratrol and/or curcumin reduces the progression of experimental periodontitis in rats Corrêa 2017 · Corrêa M. G., Pires P. R., et al. · Journal of Periodontal Research DOI:10.1111/jre.12382 | 2016 | 1 | none stated | not extracted yet |
| Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant… Tamaki 2014 · Tamaki Naofumi, Cristina Orihuela-Campos Rita, et al. · Free Radical Biology and Medicine DOI:10.1016/j.freeradbiomed.2014.07.034 | 2014 | 1 | none stated | not extracted yet |
| Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol Fordham 2014 · Fordham Jezrom B., Raza Naqvi Afsar, et al. · Mediators of Inflammation DOI:10.1155/2014/938712 | 2014 | 1 | none stated | not extracted yet |
| Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol. Fordham 2014 · Fordham Jezrom B, Naqvi Afsar Raza, et al. · Mediators of inflammation PMID:24707119 | 2014 | 1 | 3 | not extracted yet |
| Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant… Tamaki 2014 · Tamaki Naofumi, Cristina Orihuela-Campos Rita, et al. · Free radical biology & medicine PMID:25091897 | 2014 | 1 | 4 | not extracted yet |
| Resveratrol Decreases Periodontal Breakdown and Modulates Local Levels of Cytokines During Periodontitis in Rats Casati 2013 · Casati Marcio Z., Algayer Carolina, et al. · Journal of Periodontology DOI:10.1902/jop.2013.120746 | 2013 | 1 | none stated | not extracted yet |
| Effects of sirtuin 1 activation on nicotine and lipopolysaccharide-induced cytotoxicity and inflammatory cytokine production in human gingival… Park 2013 · Park G-J, Kim Y-S, et al. · Journal of periodontal research PMID:23199342 | 2013 | 1 | 2 | not extracted yet |
| Resveratrol decreases periodontal breakdown and modulates local levels of cytokines during periodontitis in rats. Casati 2013 · Casati Marcio Z, Algayer Carolina, et al. · Journal of periodontology PMID:23489233 | 2013 | 1 | 2 | not extracted yet |
| Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells Rizzo 2012 · Rizzo Antonietta, Bevilacqua Nazario, et al. · Cytokine DOI:10.1016/j.cyto.2012.06.004 | 2012 | 1 | none stated | not extracted yet |
| Effects of sirtuin 1 activation on nicotine and lipopolysaccharide‐induced cytotoxicity and inflammatory cytokine production in human gingival… Park 2013 · Park G‐J., Kim Y‐S., et al. · Journal of Periodontal Research DOI:10.1111/jre.12030 | 2012 | 1 | none stated | not extracted yet |
| Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells. Rizzo 2012 · Rizzo Antonietta, Bevilacqua Nazario, et al. · Cytokine PMID:22749236 | 2012 | 1 | 4 | not extracted yet |