Primary study · included by 1 review

Resveratrol derivative-rich melinjo seed extract induces healing in a murine model of established periodontitis.

Ikeda 2018 · Ikeda Eri, Ikeda Yuichi, Wang Yongqiang, et al. · Journal of periodontology · 2018

Included by

Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Ikeda 2018 · Figures 2 to 4; Tables 1 to 3; References 25 to 34, 40 to 44
Outcome this study informsPooled effectEvidenceCertainty
IL-1β mRNA relative expression in gingiva
Resveratrol vs Periodontitis model without resveratrol (placebo or untreated)
SMD -7.73 [-14.80, -0.66]3 studies · 24 participantsGRADE not reported
TNF-α mRNA relative expression in gingiva
Resveratrol vs Periodontitis model without resveratrol (placebo or untreated)
SMD -5.00 [-12.11, 2.12]3 studies · 24 participantsGRADE not reported
IL-6 mRNA relative expression in gingiva
Resveratrol vs Periodontitis model without resveratrol (placebo or untreated)
SMD -6.90 [-14.61, 0.81]3 studies · 24 participantsGRADE not reported

1 including review in total.