Primary study · included by 2 reviews

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail.

Nikniaz et al., 2023 · Nikniaz Shabnam, Vaziri Farzane, Mansouri Reza · BMC oral health · 2023

Included by

The review does not say which of its outcomes this study informs.

Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Nikniaz 2023 · Figures 2 to 4; Tables 1 to 3; References 25 to 34, 40 to 44
Outcome this study informsPooled effectEvidenceCertainty
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo
MD -8.11 [-9.57, -6.64]3 studiesGRADE not reported
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo
MD -8.95 [-10.47, -7.43]3 studiesGRADE not reported
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo
MD -7.72 [-9.13, -6.32]4 studiesGRADE not reported
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo
MD -6.79 [-9.06, -4.51]3 studiesGRADE not reported
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo
MD -6.50 [-8.02, -4.97]3 studiesGRADE not reported
Clinical attachment level (mm)
Adjunctive resveratrol (oral, gel, mouthwash) with scaling and root planing vs Scaling and root planing alone or with placebo · Post-treatment time point most comparable across trials
MD -0.26 [-0.51, 0]3 studies · 119 participantsLow
Probing pocket depth (mm)
Adjunctive resveratrol (oral, gel, mouthwash) with scaling and root planing vs Scaling and root planing alone or with placebo · Post-treatment time point most comparable across trials
MD -0.50 [-0.72, -0.28]3 studies · 119 participantsModerate
Bleeding index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo · Post-treatment time point most comparable across trials
MD -6.82 [-12.12, -1.53]4 studies · 187 participantsLow
Plaque index (%)
Adjunctive resveratrol (oral, gel, spray, mouthwash) with non-surgical periodontal therapy or plaque control vs Non-surgical periodontal therapy or plaque control alone, or placebo · Post-treatment time point most comparable across trials
MD -12.61 [-16.41, -8.80]3 studies · 143 participantsLow

2 including reviews in total.