Primary study · included by 1 review

Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells.

Rizzo 2012 · Rizzo Antonietta, Bevilacqua Nazario, Guida Luigi, et al. · Cytokine · 2012

Included by

Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Rizzo 2012 · Figures 2 to 4; Tables 1 to 3; References 25 to 34, 40 to 44
Outcome this study informsPooled effectEvidenceCertainty
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.68 [-4.58, -0.78]3 studiesGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.50 [-5.50, -1.51]4 studies · 24 participantsGRADE not reported
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.87 [-4.76, -0.99]4 studiesGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.59 [-5.99, -1.19]3 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.52 [-4.54, -0.49]3 studiesGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.21 [-5.25, -1.17]3 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.33 [-5.80, -0.86]4 studies · 24 participantsGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.50 [-5.49, -1.51]4 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.46 [-4.30, -0.63]3 studiesGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -4.18 [-6.84, -1.52]3 studiesGRADE not reported
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.56 [-4.50, -0.62]3 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.44 [-4.29, -0.58]3 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -2.75 [-4.53, -0.96]4 studiesGRADE not reported
IL-1β protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.30 [-5.52, -1.07]3 studiesGRADE not reported
IL-8 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.21 [-5.82, -0.61]2 studies · 12 participantsGRADE not reported
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.40 [-6.22, -0.57]4 studies · 24 participantsGRADE not reported
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.40 [-6.01, -0.79]3 studiesGRADE not reported
TNF-α protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -3.25 [-5.80, -0.71]3 studiesGRADE not reported
IL-6 protein expression
Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol
SMD -4.83 [-7.84, -1.82]3 studiesGRADE not reported

1 including review in total.