Primary study · included by 1 review
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy.
Shi 2021 · Shi Junyu, Zhang Yi, Zhang Xiaomeng, et al. · Journal of nanobiotechnology · 2021
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
IL-1β mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -7.73 [-14.80, -0.66] | 3 studies · 24 participants | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.68 [-4.58, -0.78] | 3 studies | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.50 [-5.50, -1.51] | 4 studies · 24 participants | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.87 [-4.76, -0.99] | 4 studies | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.59 [-5.99, -1.19] | 3 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.52 [-4.54, -0.49] | 3 studies | GRADE not reported |
TNF-α mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -5.00 [-12.11, 2.12] | 3 studies · 24 participants | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.21 [-5.25, -1.17] | 3 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.33 [-5.80, -0.86] | 4 studies · 24 participants | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.50 [-5.49, -1.51] | 4 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.46 [-4.30, -0.63] | 3 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.14, -0.06] | 3 studies | GRADE not reported |
IL-6 mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -6.90 [-14.61, 0.81] | 3 studies · 24 participants | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -4.18 [-6.84, -1.52] | 3 studies | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.56 [-4.50, -0.62] | 3 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.44 [-4.29, -0.58] | 3 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -2.75 [-4.53, -0.96] | 4 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.11, -0.08] | 4 studies · 62 participants | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 4 studies | GRADE not reported |
IL-1β protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.30 [-5.52, -1.07] | 3 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.40 [-6.22, -0.57] | 4 studies · 24 participants | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.40 [-6.01, -0.79] | 3 studies | GRADE not reported |
TNF-α protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -3.25 [-5.80, -0.71] | 3 studies | GRADE not reported |
IL-6 protein expression Resveratrol (any formulation or concentration) vs LPS stimulation without resveratrol | SMD -4.83 [-7.84, -1.82] | 3 studies | GRADE not reported |
1 including review in total.