Primary study · included by 1 review
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model.
Tamaki 2014 · Tamaki Naofumi, Cristina Orihuela-Campos Rita, Inagaki Yuji, et al. · Free radical biology & medicine · 2014
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
IL-1β mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -7.73 [-14.80, -0.66] | 3 studies · 24 participants | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
TNF-α mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -5.00 [-12.11, 2.12] | 3 studies · 24 participants | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.14, -0.06] | 3 studies | GRADE not reported |
IL-6 mRNA relative expression in gingiva Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | SMD -6.90 [-14.61, 0.81] | 3 studies · 24 participants | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.11, -0.08] | 4 studies · 62 participants | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 4 studies | GRADE not reported |
Alveolar bone crest level (CEJ to bone crest distance, mm) Resveratrol vs Periodontitis model without resveratrol (placebo or untreated) | MD -0.10 [-0.12, -0.08] | 3 studies | GRADE not reported |
1 including review in total.