Cochrane Review Group
Schizophrenia
168 systematic reviews in Schizophrenia ask 2,589 questions. 23.2% have no studies to answer them, 27.8% rest on very low certainty evidence and 12.2% reach moderate or high certainty.
Reviews
168
Questions
2,589
current versions
No studies
23.2%
Moderate or high
12.2%
No studies 601 · 23.2%Ungraded 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Thinnest evidence
All no studies and very low questions| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table ‐ Collaborative care vs usual care Quality of life: average change in mental health component (proxy for binary quality of life) · severe mental illness Collaborative care approaches for people with severe mental illness (2024) · Cochrane | no estimate extracted | 3 studies · 227 participants | Very low |
Summary of findings table ‐ Collaborative care vs usual care Quality of life: average change in physical health component (proxy for physical health) · severe mental illness Collaborative care approaches for people with severe mental illness (2024) · Cochrane | no estimate extracted | 3 studies · 237 participants | Very low |
Summary of findings table ‐ Collaborative care vs usual care Personal recovery ‐ not reported · severe mental illness Collaborative care approaches for people with severe mental illness (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Collaborative care vs usual care Experience of care/satisfaction ‐ not reported · severe mental illness Collaborative care approaches for people with severe mental illness (2024) · Cochrane | no estimate extracted | NR | No studies |
Structured risk assessment vs standard professional care Adverse effects (escape) · aggressive behaviour in schizophrenia Risk assessment for aggressive behaviour in schizophrenia (2024) · Cochrane | RR 0.2 [0.01, 4.11] | 1 study · 200 participants | Very low |
Structured risk assessment vs standard professional care Adverse effects (fall down) · aggressive behaviour in schizophrenia Risk assessment for aggressive behaviour in schizophrenia (2024) · Cochrane | RR 0.33 [0.04, 3.15] | 1 study · 200 participants | Very low |
Structured risk assessment vs standard professional care Adverse effects (choking) · aggressive behaviour in schizophrenia Risk assessment for aggressive behaviour in schizophrenia (2024) · Cochrane | RR 0.2 [0.01, 4.11] | 1 study · 200 participants | Very low |
Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control Adverse events ‐ participants with at least one adverse event ‐ < 12 months · first‐episode or recent‐onset psychosis Cognitive behavioural therapy added to standard care for first‐episode and recent‐onset psychosis (2024) · Cochrane | RR 1.29 [0.85, 1.97] | 1 study · 43 participants | Very low |
Summary of findings table ‐ CBT without antipsychotics vs antipsychotics Adverse events ‐ Participants with at least one AE (separated time points) ‐ < 12 months · schizophrenia Cognitive behavioural therapy without medication for schizophrenia (2024) · Cochrane | RR 0.47 [0.21, 1.07] | 1 study · 40 participants | Very low |
Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics Mental state ‐ general: mean endpoint overall symptoms scales (PANSS/BPRS) (high = poor) (separated time points) ‐ < 12 months · schizophrenia Cognitive behavioural therapy without medication for schizophrenia (2024) · Cochrane | no estimate extracted | 3 studies · 125 participants | Very low |
Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics Global state ‐ number of participants with relapse/exacerbations of psychosis (separated time points) ‐ < 12 months · schizophrenia Cognitive behavioural therapy without medication for schizophrenia (2024) · Cochrane | RR 2.89 [0.12, 67.75] | 1 study · 90 participants | Very low |
Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics Leaving the study early ‐ for any reason ‐ overall acceptability (separated time points) ‐ < 12 months · schizophrenia Cognitive behavioural therapy without medication for schizophrenia (2024) · Cochrane | RR 0.7 [0.12, 4.11] | 2 studies · 90 participants | Very low |
Reviews 168
Day hospital versus admission for acute psychiatric disorders
CochraneSoF table
7 questions
Early intervention for psychosis
CochraneSoF table
9 questions
Aripiprazole versus placebo for schizophrenia
CochraneSoF table
4 questions
Family intervention for schizophrenia
CochraneSoF table
6 questions
Zotepine versus other atypical antipsychotics for schizophrenia
CochraneSoF table
14 questions
Antipsychotic switching for people with schizophrenia who have neuroleptic‐induced weight or metabolic problems
CochraneSoF table
21 questions
Chlorpromazine for psychosis induced aggression or agitation
CochraneSoF table
6 questions
Levomepromazine for schizophrenia
CochraneSoF table
12 questions
Sulpiride augmentation for schizophrenia
CochraneSoF table
7 questions
Clozapine versus typical neuroleptic medication for schizophrenia
CochraneSoF table
14 questions
Intercessory prayer for the alleviation of ill health
CochraneSoF table
11 questions
Day hospital versus outpatient care for people with schizophrenia
CochraneSoF table
7 questions
Risperidone dose for schizophrenia
CochraneSoF table
52 questions
Monetary incentives for schizophrenia
CochraneSoF table
1 questions
Morita therapy for schizophrenia
CochraneSoF table
2 questions
Beta‐blocker supplementation of standard drug treatment for schizophrenia
CochraneSoF table
6 questions
Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness
CochraneSoF table
4 questions
Prompts to encourage appointment attendance for people with serious mental illness
CochraneSoF table
8 questions