Cochrane · systematic review · CD007445
Chlorpromazine for psychosis induced aggression or agitation
Ahmed, U, Jones, H, Adams, CE · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 5 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CHLORPROMAZINE compared to HALOPERIDOL for psychosis induced aggression or agitation
Population: patients with psychosis induced aggression or agitation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global outcome: Number of additional injections ‐ 2‐4 injections CHLORPROMAZINE vs HALOPERIDOL | RR 0.9 [0.52, 1.55] | 1 study · 30 participants | Very low Downgraded: risk of bias |
Global outcome: Number of additional injections ‐ 5 or more CHLORPROMAZINE vs HALOPERIDOL | RR 0.75 [0.2, 2.79] | 1 study · 30 participants | Very low Downgraded: risk of bias |
Adverse effects ‐ cardiovascular ‐ hypotension CHLORPROMAZINE vs HALOPERIDOL | RR 5 [0.26, 96.13] | 1 study · 30 participants | Very low Downgraded: risk of bias |
Adverse effects ‐ movement disorders ‐ extrapyramidal side effects CHLORPROMAZINE vs HALOPERIDOL | no estimate extracted | 1 study · 30 participants | Ungraded |
Adverse effects ‐ seizures CHLORPROMAZINE vs HALOPERIDOL | RR 3 [0.13, 68.26] | 1 study · 30 participants | Very low Downgraded: risk of bias |
Leaving the study early CHLORPROMAZINE vs HALOPERIDOL | RR 2 [0.2, 19.78] | 1 study · 30 participants | Very low Downgraded: risk of bias |