Non-Cochrane · aetiology · PM42045923
Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.
Zulkapli Rahayu, Sallehuddin Nusaibah, Omar Nashuha, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-08407-2
Findings
Population Adults (30-65 years) with periodontitis and coronary artery disease or cardiovascular risk indicators
8 findings
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | C-reactive protein level Baseline · Cardiology and dental clinics · Random-effects model; trim-and-fill adjusted (1 imputed study) | SMD 0.3930 GRADE not reported 5 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | C-reactive protein level Baseline · Cardiology and dental clinics · Fixed-effect model | SMD 0.501 [0.275, 0.728] GRADE not reported 5 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | Interleukin-6 level Baseline · Cardiology and dental clinics · Random-effects model | SMD 0.166 [-0.111, 0.443] GRADE not reported 3 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | C-reactive protein level Baseline · Cardiology and dental clinics · Random-effects model | SMD 0.573 [0.065, 1.082] GRADE not reported 5 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | Interleukin-6 level Baseline · Cardiology and dental clinics · Fixed-effect model; trim-and-fill adjusted (2 imputed studies) | SMD 0.1424 [-0.0769, 0.3616] GRADE not reported 3 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | C-reactive protein level Baseline · Cardiology and dental clinics · Fixed-effect model; trim-and-fill adjusted (1 imputed study) | SMD 0.3708 GRADE not reported 5 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | Interleukin-6 level Baseline · Cardiology and dental clinics · Fixed-effect model | SMD 0.166 [-0.111, 0.443] GRADE not reported 3 studies |
| Periodontitis with CAD or cardiovascular risk indicators (exposure) | Controls without periodontitis and/or without CAD or cardiovascular risk indicators | Interleukin-6 level Baseline · Cardiology and dental clinics · Random-effects model; trim-and-fill adjusted (2 imputed studies) | SMD 0.1424 [-0.0769, 0.3616] GRADE not reported 3 studies |
Included primary studies 35
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Montenegro 2019 Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary… PMID:30761568 | 2019 | 1 other review | C-reactive protein level; Interleukin-6 level | not extracted yet |
| Bagavad Gita 2019 Dysregulation of miR‐146a by periodontal pathogens: A risk for acute coronary syndrome DOI:10.1002/jper.18-0466 | 2019 | this review only | not stated | not extracted yet |
| Bagavad Gita 2019 Dysregulation of miR-146a by periodontal pathogens: A risk for acute coronary syndrome. PMID:30618100 | 2019 | this review only | not stated | not extracted yet |
| Cullinan 2015 The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): A… DOI:10.1902/jop.2015.140716 | 2015 | this review only | not stated | not extracted yet |
| Cullinan 2015 The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): A… PMID:25741582 | 2015 | this review only | not stated | not extracted yet |
| D'Aiuto 2006 Periodontal infections cause changes in traditional and novel cardiovascular risk factors: Results from a randomized controlled clinical… DOI:10.1016/j.ahj.2005.06.018 | 2006 | this review only | C-reactive protein level; Interleukin-6 level | not extracted yet |
| D'Aiuto 2006 Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical… PMID:16644317 | 2006 | this review only | C-reactive protein level; Interleukin-6 level | not extracted yet |
| Fedele 2011 Common oral mucosal diseases, systemic inflammation, and cardiovascular diseases in a large cross-sectional US survey DOI:10.1016/j.ahj.2010.11.009 | 2011 | this review only | not stated | not extracted yet |
| Fedele 2011 Common oral mucosal diseases, systemic inflammation, and cardiovascular diseases in a large cross-sectional US survey. PMID:21315218 | 2011 | this review only | not stated | not extracted yet |
| Flores 2014 Periodontal Status Affects C‐Reactive Protein and Lipids in Patients With Stable Heart Disease From a Tertiary Care Cardiovascular Clinic DOI:10.1902/jop.2013.130255 | 2014 | this review only | not stated | not extracted yet |
| Flores 2014 Periodontal status affects C-reactive protein and lipids in patients with stable heart disease from a tertiary care cardiovascular clinic. PMID:23805809 | 2014 | this review only | not stated | not extracted yet |
| Gorska 2019 Periodontal Status of Survivors of Acute Myocardial Infarction: A Case-Control Study DOI:10.5604/01.3001.0013.0621 | 2019 | this review only | not stated | not extracted yet |
| Ilango 2023 Association of pentraxin in periodontitis patients with coronary artery disease. PMID:38434506 | 2023 | this review only | not stated | not extracted yet |
| Joseph 2011 Elevated Plasma Homocysteine Levels in Chronic Periodontitis: A Hospital‐Based Case‐Control Study DOI:10.1902/jop.2010.100271 | 2011 | this review only | not stated | not extracted yet |
| Joseph 2011 Elevated plasma homocysteine levels in chronic periodontitis: a hospital-based case-control study. PMID:20831374 | 2011 | this review only | not stated | not extracted yet |
| Lobo 2020 Treating periodontal disease in patients with myocardial infarction: A randomized clinical trial DOI:10.1016/j.ejim.2019.08.012 | 2020 | this review only | not stated | not extracted yet |
| Lobo 2020 Treating periodontal disease in patients with myocardial infarction: A randomized clinical trial. PMID:31810741 | 2020 | this review only | not stated | not extracted yet |
| Miyoshi 2018 Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population DOI:10.1111/jre.12537 | 2018 | this review only | not stated | not extracted yet |
| Miyoshi 2018 Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population. PMID:29446092 | 2018 | this review only | not stated | not extracted yet |
| Montenegro 2019 Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary… DOI:10.1111/jcpe.13085 | 2019 | this review only | C-reactive protein level; Interleukin-6 level | not extracted yet |
| Pejcic 2011 matched by author and year (probable) | NR | this review only | C-reactive protein level | not extracted yet |
| Rizzo 2012 Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study DOI:10.1007/s12192-011-0315-1 | 2012 | this review only | not stated | not extracted yet |
| Rizzo 2012 Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study. PMID:22215516 | 2012 | this review only | not stated | not extracted yet |
| Saffi 2018 Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial DOI:10.1111/odi.12909 | 2018 | this review only | not stated | not extracted yet |
| Saffi 2018 Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial. PMID:29873864 | 2018 | this review only | not stated | not extracted yet |
| Sanikop 2022 Assessment of Serum Parameters in Stable Coronary Artery Disease Patients in Correlation with Healthy and Chronic Periodontitis Patients. PMID:35466295 | 2022 | this review only | C-reactive protein level | not extracted yet |
| Sebring 2024 Primary apical periodontitis correlates to elevated levels of interleukin‐8 in a Swedish population: A report from the PAROKRANK study DOI:10.1111/iej.13987 | 2023 | this review only | not stated | not extracted yet |
| Sebring 2024 Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: A report from the PAROKRANK study. PMID:38290211 | 2024 | this review only | not stated | not extracted yet |
| Seinost 2020 Periodontal treatment and vascular inflammation in patients with advanced peripheral arterial disease: A randomized controlled trial DOI:10.1016/j.atherosclerosis.2020.09.019 | 2020 | this review only | not stated | not extracted yet |
| Seinost 2020 Periodontal treatment and vascular inflammation in patients with advanced peripheral arterial disease: A randomized controlled trial. PMID:33032234 | 2020 | this review only | not stated | not extracted yet |
| Sitompul 2023 Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic… DOI:10.3390/genes14051073 | 2023 | this review only | C-reactive protein level; Interleukin-6 level | not extracted yet |
| Sitompul 2023 Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic… PMID:37239434 | 2023 | this review only | C-reactive protein level; Interleukin-6 level | not extracted yet |
| Teeuw 2015 A Lead ANRIL Polymorphism Is Associated with Elevated CRP Levels in Periodontitis: A Pilot Case-Control Study DOI:10.1371/journal.pone.0137335 | 2015 | this review only | not stated | not extracted yet |
| Teeuw 2015 A Lead ANRIL Polymorphism Is Associated with Elevated CRP Levels in Periodontitis: A Pilot Case-Control Study. PMID:26348353 | 2015 | this review only | not stated | not extracted yet |
| Zanella 2012 The Association between Oral Health and Atherosclerotic Coronary Artery Disease in Patients submitted to Coronary Angiography: a… DOI:10.1016/s2214-1235(15)30049-1 | 2012 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Changes in Serum C-Reactive Protein Following Nonsurgical Periodontal Therapy: A Systematic Review and Meta-Analysis. (2026) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (30-65 years) attending cardiology or dental clinics | Adults with chronic periodontitis and CAD (acute n=4 studies, stable n=16 studies) or CVD risk indicators (n=20 studies) |
| Intervention | Adults with periodontitis and either confirmed CAD or cardiovascular disease-related risk indicators (exposure) | Periodontitis with CAD or CVD risk indicators (n=20 studies) |
| Comparison | Individuals without periodontitis and/or without CAD or CVD risk indicators, or individuals with different periodontal status | Controls without periodontitis and/or CAD, or different periodontal status (n=20 studies) |
| Outcomes | Differences in quantitative biomarker levels (e.g., CRP, IL-6, TNF-alpha, other inflammatory biomarkers) in serum, plasma, saliva or other samples | CRP/hs-CRP (n=14+3 studies reporting; 5 pooled); IL-6 (n=8 reporting; 3 pooled); IL-1beta (n=3); IL-8 (n=2); TNF-alpha (n=1) |
| Study designs | Observational studies and randomized controlled trials; original full articles in English | 14 observational studies and 6 RCTs (n=20) |
| Timing | Not specified | Baseline biomarker levels (some post-periodontal-therapy changes reported narratively) |