Primary study · included by 1 review

Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial.

D'Aiuto 2006 · D'Aiuto Francesco, Parkar Mohamed, Nibali Luigi, et al. · American heart journal · 2006

Included by

Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.

Non-Cochrane · aetiology · 2026 · cited as D'Aiuto 2006 · Table 1; Fig. 3 and Fig. 5; References

Outcome this study informs	Pooled effect	Evidence	Certainty
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.166 [-0.111, 0.443]	3 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.573 [0.065, 1.082]	5 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.3930	5 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.501 [0.275, 0.728]	5 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.1424 [-0.0769, 0.3616]	3 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.3708	5 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.166 [-0.111, 0.443]	3 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.1424 [-0.0769, 0.3616]	3 studies	GRADE not reported

1 including review in total.