Primary study · included by 2 reviews

Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months.

Montenegro 2019 · Montenegro Marlon M, Ribeiro Ingrid W J, Kampits Cassio, et al. · Journal of clinical periodontology · 2019

Included by

Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.

Non-Cochrane · aetiology · 2026 · cited as Montenegro 2019 · Table 1; Fig. 3 and Fig. 5; References

Outcome this study informs	Pooled effect	Evidence	Certainty
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.166 [-0.111, 0.443]	3 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.573 [0.065, 1.082]	5 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.3930	5 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.501 [0.275, 0.728]	5 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.1424 [-0.0769, 0.3616]	3 studies	GRADE not reported
C-reactive protein level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.3708	5 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.166 [-0.111, 0.443]	3 studies	GRADE not reported
Interleukin-6 level Periodontitis with CAD or cardiovascular risk indicators (exposure) vs Controls without periodontitis and/or without CAD or cardiovascular risk indicators · Baseline	SMD 0.1424 [-0.0769, 0.3616]	3 studies	GRADE not reported

Changes in Serum C-Reactive Protein Following Nonsurgical Periodontal Therapy: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Montenegro 2019 · Table 1; References

Outcome this study informs	Pooled effect	Evidence	Certainty
Serum C-reactive protein (mg/L), mean reduction from baseline Nonsurgical periodontal therapy vs Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) · 3 months	MD 2.95 [-0.5, 6.4]	1 study · 82 participants	Moderate
Serum C-reactive protein (mg/L), mean reduction from baseline Nonsurgical periodontal therapy vs Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) · 3 months	MD 2.95 [-1.05, 6.95]	1 study · 82 participants	GRADE not reported
Serum C-reactive protein (mg/L), mean reduction from baseline Nonsurgical periodontal therapy vs Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) · 3 months	MD 2.95 [0.16, 5.74]	1 study · 82 participants	GRADE not reported

2 including reviews in total.