Non-Cochrane · intervention · PM42652655
Changes in Serum C-Reactive Protein Following Nonsurgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
Montoya-Carralero José María, Ávila-Villasmil Rebeca, Romo-García María Fernanda, et al. · Journal of clinical medicine · 2026 · PubMed · doi:10.3390/jcm15166251
Findings
6 findings
| Population | ||||
|---|---|---|---|---|
| Adults (>18 years) with periodontitis | Nonsurgical periodontal therapy (scaling and root planing / periodontal debridement) | Baseline (pretreatment values in the same participants; no control group) | Serum C-reactive protein (mg/L), mean reduction from baseline 8 weeks to 12 months follow-up · Clinical studies (one cohort of maintenance hemodialysis patients; one of stable coronary artery disease; others systemically healthy) · Sensitivity analysis: assumed pre-post correlation r = 0.75 | MD 1.11 [0.2, 2.01] GRADE not reported 3 studies · 119 participants |
| Adults (>18 years) with periodontitis | Nonsurgical periodontal therapy (scaling and root planing / periodontal debridement) | Baseline (pretreatment values in the same participants; no control group) | Serum C-reactive protein (mg/L), mean reduction from baseline 8 weeks to 12 months follow-up · Clinical studies (one cohort of maintenance hemodialysis patients; one of stable coronary artery disease; others systemically healthy) · Sensitivity analysis: assumed pre-post correlation r = 0.25 | MD 1.11 [0.22, 2.01] GRADE not reported 3 studies · 119 participants |
| Adults with periodontitis | Nonsurgical periodontal therapy | Pretreatment baseline (within-participant) | Serum C-reactive protein (mg/L), mean reduction 8 weeks to 12 months follow-up Unresolved: the two extractors disagree on this row. | MD 1.11 [0.21, 2.01] Very low Downgraded: imprecision, inconsistency 3 studies · 119 participants |
| Adults (>18 years) with periodontitis | Nonsurgical periodontal therapy | Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) | Serum C-reactive protein (mg/L), mean reduction from baseline 3 months · Clinical studies (one cohort of maintenance hemodialysis patients; one of stable coronary artery disease; others systemically healthy) · Primary analysis (assumed pre-post correlation r = 0.50) | MD 2.95 [-0.5, 6.4] Moderate Downgraded: imprecision 1 study · 82 participants |
| Adults (>18 years) with periodontitis | Nonsurgical periodontal therapy | Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) | Serum C-reactive protein (mg/L), mean reduction from baseline 3 months · Clinical studies (one cohort of maintenance hemodialysis patients; one of stable coronary artery disease; others systemically healthy) · Sensitivity analysis: assumed pre-post correlation r = 0.25 | MD 2.95 [-1.05, 6.95] GRADE not reported 1 study · 82 participants |
| Adults (>18 years) with periodontitis | Nonsurgical periodontal therapy | Delayed periodontal treatment control (supragingival prophylaxis and oral hygiene instruction) | Serum C-reactive protein (mg/L), mean reduction from baseline 3 months · Clinical studies (one cohort of maintenance hemodialysis patients; one of stable coronary artery disease; others systemically healthy) · Sensitivity analysis: assumed pre-post correlation r = 0.75 | MD 2.95 [0.16, 5.74] GRADE not reported 1 study · 82 participants |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Montenegro 2019 Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary… PMID:30761568 | 2019 | 1 other review | Serum C-reactive protein (mg/L), mean reduction from baseline | not extracted yet |
| Isola 2024 Effects of minimally invasive non-surgical therapy on C-reactive protein, lipoprotein-associated phospholipase A2, and clinical outcomes… PMID:38696664 | 2024 | this review only | not stated | not extracted yet |
| Kiany Yazdi 2013 Effect of nonsurgical periodontal treatment on C-reactive protein levels in maintenance hemodialysis patients. PMID:23534529 | 2013 | this review only | Serum C-reactive protein (mg/L), mean reduction | not extracted yet |
| Patil 2013 Effect of periodontal therapy on serum C-reactive protein levels in patients with gingivitis and chronic periodontitis: a… PMID:23811651 | 2013 | this review only | Serum C-reactive protein (mg/L), mean reduction | not extracted yet |
| Zekonis 2016 Effect of Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide on Clinical Periodontal Parameters, Markers of Systemic… PMID:27743448 | 2016 | this review only | Serum C-reactive protein (mg/L), mean reduction | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis. (2026) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults older than 18 years with clinical diagnosis of periodontitis (chronic or severe) | Adults with periodontitis (n=119 in pooled analysis; hemodialysis, stable coronary artery disease and systemically healthy cohorts) |
| Intervention | Nonsurgical periodontal treatment (scaling and root planing, debridement, full-mouth debridement) | Nonsurgical periodontal therapy, including minimally invasive nonsurgical therapy (5 studies) |
| Comparison | Pretreatment vs posttreatment in the same patients; treated vs control groups when design allowed | Baseline pre-post (3 studies); delayed treatment control (1 trial, n=82); active comparator (1 trial, narrative) |
| Outcomes | Change in serum CRP after periodontal treatment | Serum CRP mg/L (within-participant reduction; controlled difference in change) |
| Study designs | Randomized and nonrandomized clinical studies published in the last 15 years in English or Spanish | 3 uncontrolled pre-post studies; 2 randomized trials (5 included) |
| Timing | Not specified | Follow-up 8 weeks to 12 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | No | No | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | No | No | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Yes | RCT: Yes · NRSI: Yes | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: N/A · NRSI: Yes | RCT: N/A · NRSI: Yes | yes |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |