Non-Cochrane · aetiology · PM41440353
Periodontitis and Oral Pathogens in Colorectal Cancer: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Chauca-Bajaña Luis, Ordoñez Balladares Andrea, Lorenzo-Pouso Alejandro Ismael, et al. · Dentistry journal · 2025 · PubMed · doi:10.3390/dj13120595
Findings
8 findings
| Population | ||||
|---|---|---|---|---|
| Adults in observational studies | Periodontitis or exposure to oral pathogens (periodontal history, serum IgG to oral bacteria, F. nucleatum in tissue) | No periodontitis or no oral pathogen exposure | Incident colorectal cancer | HR 1.70 [1.33, 2.19] GRADE not reported 5 studies |
| Adults with colorectal cancer and controls without colorectal cancer | Detection of Porphyromonas gingivalis in stool or tumor tissue | No detection of P. gingivalis (controls) | Diagnosis of colorectal cancer (detection in CRC vs controls) Case-control studies of P. gingivalis detection | OR 9.65 [1.24, 74.86] GRADE not reported 2 studies |
| Patients with colorectal cancer | Tumor or fecal presence of Porphyromonas gingivalis | Absence of P. gingivalis | Overall survival | HR 2.56 [1.81, 3.63] GRADE not reported 3 studies |
| Patients with colorectal cancer | Porphyromonas gingivalis detection | None | Pooled prevalence of P. gingivalis in colorectal cancer | Proportion 0.21 [0.08, 0.38] GRADE not reported 4 studies · 666 participants |
| Adults with and without colorectal cancer | Presence or detection of Fusobacterium nucleatum | No detection of F. nucleatum | Development of colorectal cancer (pooled hazard ratio) | HR 3.70 [1.21, 11.32] GRADE not reported 5 studies |
| Adults with and without colorectal cancer | Presence or detection of Fusobacterium nucleatum | No detection of F. nucleatum | Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool) | RR 3.20 [1.76, 5.82] GRADE not reported 6 studies · 1044 participants |
| Patients with colorectal cancer | High intratumoral or fecal Fusobacterium nucleatum load | Low or no F. nucleatum | Overall survival | HR 1.52 [1.07, 2.16] GRADE not reported 4 studies |
| Patients with colorectal cancer | Fusobacterium nucleatum detection in tumor tissue | None | Pooled prevalence of F. nucleatum in colorectal tumor tissue | Proportion 0.45 [0.34, 0.57] GRADE not reported 6 studies · 818 participants |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Fu 2022 Is periodontitis a risk factor of benign or malignant colorectal tumor? A population-based cohort study. PMID:34854493 | 2022 | 1 other review | Incident colorectal cancer | not extracted yet |
| Castellarin 2012 Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. PMID:22009989 | 2012 | this review only | Incident colorectal cancer | not extracted yet |
| Chen 2022 Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer. PMID:35678912 | 2022 | this review only | Development of colorectal cancer (pooled hazard ratio); Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool); Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| de Carvalho 2019 Microbiota Profile and Impact of Fusobacterium nucleatum in Colorectal Cancer Patients of Barretos Cancer Hospital. PMID:31555583 | 2019 | this review only | Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool); Overall survival; Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| Debertin 2023 Antibodies to oral pathobionts and colon cancer risk in the CLUE I cohort study. PMID:36971101 | 2023 | this review only | Incident colorectal cancer | not extracted yet |
| Eisele 2021 Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study. PMID:33935016 | 2021 | this review only | Overall survival | not extracted yet |
| El-Sokkary 2022 Molecular characterization of gut microbial structure and diversity associated with colorectal cancer patients in Egypt. PMID:36721476 | 2022 | this review only | Diagnosis of colorectal cancer (detection in CRC vs controls); Pooled prevalence of P. gingivalis in colorectal cancer | not extracted yet |
| Kato 2016 Oral microbiome and history of smoking and colorectal cancer. PMID:28111632 | 2016 | this review only | Incident colorectal cancer | not extracted yet |
| Kerdreux 2023 Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. PMID:37325051 | 2023 | this review only | Diagnosis of colorectal cancer (detection in CRC vs controls); Overall survival; Pooled prevalence of P. gingivalis in colorectal cancer | not extracted yet |
| Lo 2022 Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant… PMID:36303164 | 2022 | this review only | Development of colorectal cancer (pooled hazard ratio); Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool); Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| Lund Håheim 2022 Low level of antibodies to the oral bacterium Tannerella forsythia predicts bladder cancers and Treponema denticola predicts colon and… PMID:35994451 | 2022 | this review only | Incident colorectal cancer | not extracted yet |
| Mima 2016 Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. PMID:26311717 | 2016 | this review only | Overall survival | not extracted yet |
| Mima 2020 Mucosal cancer-associated microbes and anastomotic leakage after resection of colorectal carcinoma. PMID:31765952 | 2020 | this review only | Development of colorectal cancer (pooled hazard ratio); Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| Rye 2022 Fusobacterium nucleatum and Bacteroides fragilis detection in colorectal tumours: Optimal target site and correlation with total bacterial… PMID:34995318 | 2022 | this review only | Development of colorectal cancer (pooled hazard ratio); Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool); Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| Wang 2021 Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome. PMID:34003774 | 2021 | this review only | Overall survival; Pooled prevalence of P. gingivalis in colorectal cancer | not extracted yet |
| Xie 2022 Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis. PMID:36262751 | 2022 | this review only | Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool); Overall survival; Pooled prevalence of F. nucleatum in colorectal tumor tissue | not extracted yet |
| Yu 2017 Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. PMID:26408641 | 2017 | this review only | Development of colorectal cancer (pooled hazard ratio); Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies. (2026) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults enrolled in observational studies (cohort, case-control, population-based) and human molecular studies | Adults with colorectal cancer and controls (17 included studies) |
| Intervention | Clinical or radiographic diagnosis of periodontitis and/or detection of oral bacteria (F. nucleatum, P. gingivalis, T. forsythia) in tissue, biological fluids or fecal microbiome by molecular techniques | Periodontitis or oral pathogen exposure (n=5 studies); F. nucleatum detection (n=9 studies); P. gingivalis detection (n=3 studies) |
| Comparison | Adults without periodontitis or without a pathogenic oral microbiome | Controls without periodontitis or CRC, adjacent normal tissue, or pathogen-negative or low-load tumors |
| Outcomes | Primary: incident colorectal cancer. Secondary: overall survival and recurrence-free/progression-free survival; prevalence or relative abundance of periodontal pathogens in CRC versus non-CRC controls | Incident CRC risk (n=5; Fn RR n=6, Fn HR n=5); P. gingivalis detection in CRC (n=2); overall survival (Pg n=3, Fn n=4); prevalence (Pg n=4, Fn n=6) |
| Study designs | Observational studies (prospective cohorts, case-control, population-based) and human molecular studies | Observational studies: case-control, prospective and retrospective cohorts, cross-sectional |
| Timing | Not specified | Not specified |