Primary study · included by 1 review

Fusobacterium nucleatum and Bacteroides fragilis detection in colorectal tumours: Optimal target site and correlation with total bacterial load.

Rye 2022 · Rye Marie S, Garrett Kerryn L, Holt Robert A, et al. · PloS one · 2022

Included by

Periodontitis and Oral Pathogens in Colorectal Cancer: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.

Non-Cochrane · aetiology · 2025 · cited as Rye 2022 · Figure 7A; Table 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Pooled prevalence of F. nucleatum in colorectal tumor tissue Fusobacterium nucleatum detection in tumor tissue	Proportion 0.45 [0.34, 0.57]	6 studies · 818 participants	GRADE not reported
Development of colorectal cancer (pooled hazard ratio) Presence or detection of Fusobacterium nucleatum vs No detection of F. nucleatum	HR 3.70 [1.21, 11.32]	5 studies	GRADE not reported
Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool) Presence or detection of Fusobacterium nucleatum vs No detection of F. nucleatum	RR 3.20 [1.76, 5.82]	6 studies · 1044 participants	GRADE not reported

1 including review in total.