Primary study · included by 2 reviews

Is periodontitis a risk factor of benign or malignant colorectal tumor? A population-based cohort study.

Fu 2022 · Fu Martin M, Chien Wu-Chien, Chung Chi-Hsiang, et al. · Journal of periodontal research · 2022

Included by

Periodontitis and Oral Pathogens in Colorectal Cancer: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.

Non-Cochrane · aetiology · 2025 · cited as Fu 2022 · Figure 2; Table 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Incident colorectal cancer Periodontitis or exposure to oral pathogens (periodontal history, serum IgG to oral bacteria, F. nucleatum in tissue) vs No periodontitis or no oral pathogen exposure	HR 1.70 [1.33, 2.19]	5 studies	GRADE not reported

Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.

Non-Cochrane · aetiology · 2026 · cited as Fu 2022 · Table 1; References 11, 18-31

Outcome this study informs	Pooled effect	Evidence	Certainty
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.22 [1.03, 1.44]	7 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.25 [1.04, 1.50]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.22 [1.01, 1.47]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.39 [1.01, 1.90]	3 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.16 [0.94, 1.42]	3 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.26 [1.02, 1.57]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.12 [0.91, 1.38]	5 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.22 [1.01, 1.47]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.22 [1.02, 1.47]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 0.99 [0.74, 1.33]	2 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.07 [0.91, 1.25]	7 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 0.96 [0.84, 1.09]	4 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.24 [1.04, 1.48]	11 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.64 [1.50, 1.79]	2 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.21 [1.00, 1.45]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.14 [1.01, 1.29]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.29 [1.08, 1.55]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.28 [1.06, 1.55]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.22 [0.84, 1.79]	4 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.62 [1.49, 1.76]	5 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.23 [1.03, 1.47]	10 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.14 [1.04, 1.25]	4 studies	GRADE not reported
Colorectal cancer risk Periodontitis vs No periodontitis	HR 1.26 [1.05, 1.53]	10 studies	GRADE not reported

2 including reviews in total.