evidencegaps
Primary study · included by 1 review

Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis.

Xie 2022 · Xie Yanxuan, Jiao Xiaoyang, Zeng Mi, et al. · Cancer management and research · 2022

Included by

Periodontitis and Oral Pathogens in Colorectal Cancer: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Non-Cochrane · aetiology · 2025 · cited as Xie 2022 · Figure 7B; Table 2
Outcome this study informsPooled effectEvidenceCertainty
Pooled prevalence of F. nucleatum in colorectal tumor tissue
Fusobacterium nucleatum detection in tumor tissue
Proportion 0.45 [0.34, 0.57]6 studies · 818 participantsGRADE not reported
Overall survival
High intratumoral or fecal Fusobacterium nucleatum load vs Low or no F. nucleatum
HR 1.52 [1.07, 2.16]4 studiesGRADE not reported
Development of colorectal cancer (pooled risk ratio, tumor vs control or normal tissue or stool)
Presence or detection of Fusobacterium nucleatum vs No detection of F. nucleatum
RR 3.20 [1.76, 5.82]6 studies · 1044 participantsGRADE not reported

1 including review in total.