Breast and Bottle Feeding as Risk Factors for Dental Caries: A Systematic Review and Meta-Analysis.
Avila Walesca M, Pordeus Isabela A, Paiva Saul M, et al. · PloS one · 2015 · PubMed · doi:10.1371/journal.pone.0142922
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children with exclusively primary dentition (age ≤71 months) | Children aged 18 to 60 months with primary dentition (n=7) |
| Intervention | Breastfeeding | Breastfeeding (n=7) |
| Comparison | Bottle feeding | Bottle feeding (n=7) |
| Outcomes | Dental caries | Presence of dental caries (n=7) |
| Study designs | Observational cross-sectional, case-control and cohort studies, and clinical trials | 5 cross-sectional, 1 case-control, 1 cohort (n=7); meta-analysis of 2 cross-sectional studies |
| Timing | Not specified (no date restriction on search) | Single cross-sectional assessment in early childhood for most studies; 1 cohort followed to age 24 to 30 months |
Search date: March 2014; updated March 2015. Databases: PubMed; Cochrane Library; Web of Science; Controlled-trials Database of Clinical Trials; ClinicalTrials.gov (US NIH); National Institute for Health and Clinical Excellence (NICE); LILACS; grey literature
Questions and results
Breastfeeding vs Bottle feeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Presence of dental caries In a meta-analysis of two cross-sectional studies, breastfed children had lower odds of dental caries than bottle-fed children (OR 0.43, 95% CI 0.23 to 0.80); certainty was not formally graded. Source: Fig 3 (forest plot); Results (Meta-analysis); Abstract · same question in other reviews | OR 0.43 [0.23, 0.80] | 2 studies · 620 participants | Ungraded |
Presence of dental caries Across seven observational studies, four found significantly less dental caries with breastfeeding and three found no significant difference; the review judged the overall ungraded evidence to favour breastfeeding as protective. Source: Abstract; Results (Study characteristics; Meta-analysis); Discussion (Strength of evidence) · same question in other reviews | Four studies showed that bottle fed children had more dental caries (p<0.05), while three studies found no such association (p>0.05); the review concluded that breastfeeding can protect against dental caries in early… | 7 studies | Ungraded |
Included primary studies 11
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Majorana et al. (2014) Feeding and smoking habits as cumulative risk factors for early childhood caries in toddlers, after adjustment for several behavioral… PMID:24528500 | 4 other reviews | Presence of dental caries | not extracted yet | not extracted yet |
| Roberts et al. (1994) matched by author and year (probable) | 2 other reviews | Presence of dental caries | not extracted yet | not extracted yet |
| Qadri et al. (2012) matched by author and year (probable) | 1 other review | Presence of dental caries | not extracted yet | not extracted yet |
| Al-Dashti et al. (1995) matched by author and year (probable) | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Al-Dashti et al. (1995) Breast feeding, bottle feeding and dental caries in Kuwait, a country with low-fluoride levels in the water supply. PMID:7697564 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Du et al. (2000) Caries patterns and their relationship to infant feeding and socio-economic status in 2-4-year-old Chinese children. PMID:11197198 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Du et al. (2007) Caries in preschool children and its risk factors in 2 provinces in China. PMID:17263154 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Perera et al. (2014) DOI:10.6133/apjcn.2014.23.2.13 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Perera et al. (2014) Effect of feeding practices on dental caries among preschool children: a hospital based analytical cross sectional study. PMID:24901097 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Qadri et al. (2012) Early childhood caries and feeding practices in kindergarten children. PMID:22532957 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
| Roberts et al. (1994) Patterns of breast and bottle feeding and their association with dental caries in 1- to 4-year-old South African children. 2. A case… PMID:8193983 | this review only | Presence of dental caries | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).