Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in postoperative pain in the immediate postobturation period (up to 72… compared with multiple-visit root canal treatment (two or more visits) (low certainty).
1 finding from 1 review
Caries detection accuracy in unrestored molars and premolars · Dental images of human beings
The review reported 92.37% accuracy for automated caries detection in Duong et al. (Ungraded).
1 finding from 1 review
Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).
2 findings from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether boric acid changes reduction in level of contamination by particles >5 um (droplets) at… compared with water (very low certainty).
2 findings from 1 review
MD -29.3 [-32.65, -25.95]
1 study · 60 participants
Very low
MD -14.04 [-16.47, -11.61]
1 study · 60 participants
Very low
Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35)
In adults in poor-fluoridated tap water areas, dental care products contributed on average 12% of total fluoride exposure (ungraded; 1-2 studies).
3 findings from 1 review
Tooth extraction due to endodontic problems · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
It is very uncertain whether single-visit root canal treatment changes tooth extraction due to endodontic problems compared with multiple-visit root canal treatment (two or more visits) (very low certainty).
1 finding from 1 review
Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.02]
Studies not reported
Very low
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; tabulated failure rates favored resin-modified GIC.
1 finding from 1 review
Specificity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)
Visual or visual-tactile classification had a summary specificity of 0.81 (95% CrI 0.73, 0.87) for detecting enamel caries; low certainty.
2 findings from 1 review
Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Complications and side effects · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
Annual increment in DMFS (D3) · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
Oral-health-education interventions significantly reduced net increment in DMFS (SMD -1.05); no significant subgroup difference vs other interventions (P=0.74).
5 findings from 1 review
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Intervention type: oral health education
SMD -1.05 [-2.03, -0.08]
3 studies
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · WHO health-promoting-schools framework
SMD -0.57 [-1.56, 0.42]
2 studies
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Non-WHO-framework interventions
SMD -1.88 [-3.15, -0.60]
Studies not reported
GRADE not reported
Show 2 more findings
Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents
CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).
1 finding from 1 review
HbA1c (glycated haemoglobin), change · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
Periodontal treatment (subgingival instrumentation, with or without… probably leads to lower hbA1c (glycated haemoglobin), change compared with no active intervention/usual care (moderate certainty).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; the 7-second etching arm had a lower tabulated failure rate.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive periodontitis, systemic disorders…
Full-mouth scaling (FMS): scaling/root planing (subgingival… showed no clear difference in change in probing pocket depth (PPD) compared with quadrant scaling and root planing (control): SRP of each quadrant in… (low certainty).
1 finding from 1 review
Caries distribution (individual/tooth/surface level) · European adolescents aged 12–19 years
Caries distribution was skewed at individual, tooth and surface levels and too heterogeneous to meta-analyze (narrative synthesis of 11 studies; not GRADE-rated).
1 finding from 1 review
No meta-analysis possible; caries distribution reported narratively from 11 studies as skewed at individual, tooth and surface levels, changing with age at tooth and surface level (Results – Caries distribution).
11 studies
GRADE not reported
Periodontal disease (gingivitis/periodontitis) · Children or adolescents
CLWH on ART had significantly higher prevalence of periodontal disease than healthy controls (pooled OR 3.11, 95% CI 1.62 to 5.97; moderate heterogeneity).
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence fell significantly after cART compared with before cART in the same children (very low certainty).
1 finding from 1 review