Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Mobilization of community first responders (CFRs) in addition to routine emergency medical services (EMS) care vs routine EMS care

Neurological function at 30 days, measured by cerebral performance category (CPC) · adults and children more than 4 weeks old suffering from OHCA

The review found no eligible studies for this question.

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Length of hospital stay · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes length of hospital stay (days) compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Longer self‐certification vs shorter self‐certification

CBA: Average duration of sickness absence periods in days · workers
2 findings from 1 review

Interventions for involving patients in decision‐making about their health care vs attention control

Health status (a) Patient‐reported high self‐rated health at 6 months after baseline CDC Healthy Days Measure (CDC 2000): dichotomised as low (1 to 3) and high (4 to 5) · older patients with multi‐morbidity
1 finding from 1 review

Interventions for involving older patients with multi‐morbidity in decision‐making about their health care vs usual care

Health status (a) Patient‐reported high self‐rated health at 6 months after baseline CDC Healthy Days Measure (CDC 2000): dichotomised as low (1 to 3) and high (4 to 5) · older patients with multi‐morbidity

It is very uncertain whether interventions for involving older patients with multi‐morbidity in… changes health status (a) Patient‐reported high self‐rated health at 6… compared with usual care (very low certainty).

1 finding from 1 review