Cochrane · systematic review · CD012962
Rapid initiation of antiretroviral therapy for people living with HIV
Mateo‐Urdiales, A, Johnson, S, Smith, R, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 2 · 33.3%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Rapid antiretroviral therapy (ART) compared to standard care for people living with HIV
Population: people living with HIV
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at 12 months Rapid antiretroviral therapy (ART) vs standard care | RR 0.72 [0.51, 1.01] | 7 studies · 5451 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Virological suppression at 12 months Rapid antiretroviral therapy (ART) vs standard care | RR 1.18 [1.1, 1.27] | 4 studies · 2719 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Retention in care at 12 months Rapid antiretroviral therapy (ART) vs standard care | RR 1.22 [1.11, 1.35] | 6 studies · 5001 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Uptake of ART at 90 days Rapid antiretroviral therapy (ART) vs standard care | RR 1.31 [1.18, 1.45] | 4 studies · 11404 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Uptake of ART at 12 months Rapid antiretroviral therapy (ART) vs standard care | RR 1.09 [1.06, 1.12] | 4 studies · 3713 participants | Moderate Downgraded: risk of bias, imprecision |
Treatment modification Rapid antiretroviral therapy (ART) vs standard care | RR 7.89 [0.76, 81.74] | 2 studies · 977 participants | Very low Downgraded: imprecision, inconsistency |