Cochrane · systematic review · CD012767
Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery
Wrzosek, A, Jakowicka‐Wordliczek, J, Zajaczkowska, R, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Perioperative restrictive fluid therapy compared with goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery
Population: adults receiving intravenous fluids while undergoing major non‐cardiac surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Major complications (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | RR 1.61 [0.78, 3.34] | 5 studies · 484 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
All‐cause mortality (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | RD 0.03 [0, 0.06] | 6 studies · 544 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Length of hospital stay (days) Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | no estimate extracted | 5 studies · 464 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Surgery‐related complications (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | RR 1.54 [0.87, 2.72] | 4 studies · 364 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Non‐surgery‐related complications (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | RR 1 [0.52, 1.93] | 1 study · 74 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Renal failure (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | RR 1.38 [0.57, 3.36] | 4 studies · 410 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of surgical recovery assessed in any way (e.g. as a surgical recovery score) (during longest Perioperative restrictive fluid therapy vs goal‐directed fluid therapy | no estimate extracted | 1 study · 74 participants | Very low Downgraded: risk of bias, imprecision, indirectness |