Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

Early treatment may leads to higher proportion of infants receiving any pharmacotherapy for a… compared with expectant management (low certainty).

1 finding from 1 review

Early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Death · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Tuberculosis · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in tuberculosis compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Disease progression measured by opportunistic disease Opportunistic disease events · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Admission to neonatal intensive care unit · preterm prelabour rupture of membranes (PPROM)

Planned early birth probably leads to higher admission to neonatal intensive care compared with expectant management (moderate certainty).

1 finding from 1 review