Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Fluoride-releasing compomer bonding agent did not show a statistically significant reduction in new white spot lesions versus non-fluoride compomer bonding agent (very low certainty).
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
Mean DMFT in Eritrea was 2.273 (95% CI 1.884 to 2.661); certainty not graded.
1 finding from 1 review
S. mutans presence · Adolescents/teenagers undergoing orthodontic treatment
A single study found no significant difference in S. mutans presence between aligners and fixed appliances in adolescents at 1 month (RR 0.86, 95% CI 0.64 to 1.14; ungraded).
1 finding from 1 review
RR 0.86 [0.64, 1.14]
1 study
GRADE not reported
Streptococcus mutans load in the oral cavity (saliva and/or dental plaque) · Adults and children (general population)
In a sensitivity analysis assuming a 0.95 baseline-to-endpoint correlation for the sugar-free gum arm, the effect remained significant (SMD -0.55, 95% CI -0.80 to -0.30; 13 trials, I2 73%); certainty not formally graded.
2 findings from 1 review
Intervention not reported
Initiation of white spot lesions (WSL), visual-tactile assessment
The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.
1 finding from 1 review
RR 1.02 [0.82, 1.27]
Studies not reported
GRADE not reported
Dental caries · Individuals in Ethiopia assessed for dental caries
The habit of tooth cleaning was not significantly associated with dental caries (OR 0.71, 95% CI 0.17 to 2.96); certainty not graded.
1 finding from 1 review
Dental caries · Individuals in Ethiopia assessed for dental caries
Sweet food consumption was associated with significantly higher odds of dental caries (OR 2.4, 95% CI 1.91 to 3.01); certainty not graded.
1 finding from 1 review
Water samples with fluoride concentration above the acceptable range · Brazilian cities in the Northeast region with artificially fluoridated public water supplies
In the Northeast region, 0.2% of samples were above the acceptable range.
1 finding from 1 review
Prevalence 0.2
Studies not reported
GRADE not reported
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 1.69, 95% CI 1.13 to 2.53; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
Intervention not reported
Initiation of white spot lesions (WSL), visual-tactile assessment
The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.
1 finding from 1 review
RR 0.82 [0.66, 1.02]
Studies not reported
GRADE not reported
Intervention not reported
Initiation of white spot lesions (WSL), visual-tactile assessment
The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.
1 finding from 1 review
RR 0.85 [0.66, 1.10]
Studies not reported
GRADE not reported
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
For resin-based sealants, fluoride release did not significantly change WSL initiation (RR 0.71, wide CI); subgroup not separately GRADE-rated.
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Adults (general and hospital populations assessed in case-control studies)
No statistically significant difference in DMFT index between SSc patients and controls (SMD -0.03, CI includes 0); certainty ungraded.
1 finding from 1 review
Dental caries in children · Children in cross-sectional studies from Asia
Maternal smoking during pregnancy was associated with higher odds of childhood caries in the Asia subgroup.
1 finding from 1 review
OR 1.84 [1.39, 2.45]
2 studies
GRADE not reported
Iron deficiency (as defined by trialists) · Preschool children (<6 years)
In a sensitivity analysis excluding one outlier study, ECC remained associated with higher odds of iron deficiency (OR 2.76, 95% CI 2.42 to 3.13); ungraded.
2 findings from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence in primary dentition was 39.5% (95% CI 26.9 to 52.1); certainty not graded.
1 finding from 1 review
Full-mouth bleeding score (FMBS) · Adolescents/teenagers undergoing orthodontic treatment
A single study reported a lower full-mouth bleeding score with aligners versus fixed appliances in adolescents at 12 months (MD -20.44, 95% CI -22.98 to -17.90; ungraded).
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
The additional use of a sealant probably reduces the initiation of white spot lesions during fixed orthodontic treatment compared with no sealant (RR 0.70), but the certainty of evidence is very low.
1 finding from 1 review
Iron deficiency anaemia · Preschool children (<6 years)
Children with early childhood caries were more likely to have iron-deficiency anemia than caries-free children (OR 2.74, 95% CI 2.41 to 3.11); ungraded.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · Adults (general and hospital populations assessed in case-control studies)
Systemic sclerosis patients have significantly reduced mouth opening compared with controls (SMD -1.06); certainty ungraded.
1 finding from 1 review