Dental caries prevalence · European adolescents aged 15 years
Pooled caries prevalence was 0.50 (I² = 99.4%).
1 finding from 1 review
External disease-state discrimination · Oral microbiome samples from four selected case-control studies
The KEGG Orthology classifier had an approximate AUC of 0.75 in the disease-only study test set.
1 finding from 1 review
AUC 0.75
4 studies
GRADE not reported
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Caries experience · European adolescents aged 18 years
Pooled caries experience was 14.98 (I² = 88.0%).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Caries in upper primary incisors has the lowest tooth-specific predictive value for permanent-teeth caries (RR 1.6; single study; not GRADE-rated).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
MTA had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Diet-related noncommunicable diseases · Children and adolescents (general population, aged under 20 years)
No eligible studies were found.
1 finding from 1 review
Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in adults (aged…
Fluoride-containing dental care products (mainly toothpaste) contributed on average 38% (SD 27%) of total daily fluoride intake, regardless of tap-water fluoride level or age (ungraded; descriptive synthesis, no meta-analysis).
1 finding from 1 review
Intervention not reported
Caries experience - mean dmft (descriptive), primary dentition
1 finding from 1 review
Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in gingivitis between ART regimens (very low certainty).
1 finding from 1 review
Intervention not reported
Mean number of arrested caries surfaces
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; tabulated failure rates ranged from 0% to 2.9%.
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between children of low- versus high-SES parents (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Early childhood caries increases the likelihood of caries in permanent teeth roughly three-fold, but the certainty of evidence is very low (OR 3.22, 95% CI 2.80 to 3.71).
1 finding from 1 review
Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries
BLISS did not show a statistically significant reduction in overweight/obesity risk at 24 months (low certainty).
1 finding from 1 review
Intervention not reported
Food purchasing
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; glass carbomer had the highest tabulated failure range.
1 finding from 1 review
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review