Findings

What do systematic reviews say?

335 questions · 340 findings · 46 reviews · Pain, Palliative and Supportive Care

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No studies found 66 · 19.4%GRADE not reported 16 · 4.7%Very low 102 · 30%Low 68 · 20%Moderate 59 · 17.4%High 29 · 8.5%

Intervention not reported

Patient Global Impression of Change much or very much improved · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Antipsychotics for fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Depression (Scale 0 to 50) · adults with fibromyalgia

1 finding from 1 review

Antipsychotics for fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 207 participants
Very low

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
Gaonkar 2004: no differences between groups in postoperative heart rate and blood pressure. Prabhu 1999: significantly lower heart rates in the intervention group throughout the postoperative period, and no differences…
2 studies
GRADE not reported

Intervention not reported

Patient Global Impression of Change much or very much improved · adults with neuropathic pain (Trigeminal neuralgia, painful diabetic neuropathy, chronic post stroke pain)

1 finding from 1 review

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Patient Global Impression of Change much or very much improved · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change much or very much improved · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)

1 finding from 1 review

Imipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Intervention not reported

Patient Global Impression of Change very much improved (patient global evaluation of pain relief complete or good) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…

1 finding from 1 review

Levetiracetam for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 86 participants
Very low

Intervention not reported

Patient Global Impression of Change much or very much improved (patient global evaluation of pain relief complete, good or moderate) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…

1 finding from 1 review

Levetiracetam for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 86 participants
Very low

Intervention not reported

Patient Global Impression of Change much or very much improved · adults with peripheral neuropathic pain conditions

The review found no eligible studies for this question.

1 finding from 1 review

Topical lidocaine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change very much improved (PGPR "complete" or "a lot") · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)

1 finding from 1 review

Desipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 50 participants
Very low

Intervention not reported

Patient Global Impression of Change much or very much improved (PGPR "complete", "a lot", or "moderate") · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)

1 finding from 1 review

Desipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 50 participants
Very low

Intervention not reported

Patient Global Impression of Change: much or very much improved · adults with complex regional pain syndrome type 1 (lower limb)

The review found no eligible studies for this question.

1 finding from 1 review

Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Radioisotopes vs placebo

Compression of spinal cord · patients with metastatic bone pain

Radioisotopes showed no clear difference in compression of spinal cord compared with placebo (low certainty).

1 finding from 1 review

Radioisotopes for metastatic bone pain 2011 · Cochrane Headline outcomes only
RR 1.1 [0.39, 3.07]
2 studies · 270 participants
Low

Intervention not reported

Total studies: 38 Total participants: 12,985 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
38 participants
GRADE not reported

Intervention not reported

Mirtazapine RCTs: 1 Participants: 406 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Low

Intervention not reported

Duloxetine RCTs: 26 Participants: 7952 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
26 participants
Moderate

Intervention not reported

Milnacipran RCTs: 5 Participants: 3109 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
5 participants
Moderate

Summary of findings: complete control of vomiting during the overall phase (HEC) when vs treatment with aprepitant + granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: complete control of vomiting during the overall phase (HEC) when vs treatment with aprepitant + granisetron

casopitant + ondansetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
39 studies · 21642 participants
Low

Summary of findings: complete control of vomiting during the overall phase (HEC) when vs treatment with aprepitant + granisetron

rolapitant + granisetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
39 studies · 21642 participants
Moderate