Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (E-speed) pooled diagnostic odds ratio was 127.56 (95% CI 7.38 to 2203.70) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
DOR 127.56 [7.38, 2203.70]
2 studies
GRADE not reported
Specificity 0.98 [0.79, 0.998]
2 studies
GRADE not reported
AUC 0.90
2 studies
GRADE not reported
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Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (D-speed) pooled sensitivity was 0.65 (95% CI 0.57 to 0.73) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
Sensitivity 0.65 [0.57, 0.73]
1 study
GRADE not reported
Specificity 0.58 [0.42, 0.72]
1 study
GRADE not reported
AUC 0.65
1 study
GRADE not reported
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DOR 2.59 [1.24, 5.44]
1 study
GRADE not reported
Caries prevalence (early childhood caries) · Toddlers and preschool children, 2 to 6 years of age (primary dentition)
Caesarean section delivery may be associated with a modestly higher prevalence of early childhood caries than vaginal delivery (pooled OR 1.48), but the evidence is inconsistent and of very low certainty.
1 finding from 1 review
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (E-speed) pooled sensitivity was 0.80 (95% CI 0.71 to 0.87) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
Sensitivity 0.80 [0.71, 0.87]
1 study
GRADE not reported
DOR 60.37 [3.31, 1100.70]
1 study
GRADE not reported
AUC 0.94
1 study
GRADE not reported
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Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled diagnostic odds ratio was 16.6 (95% CI 4.85 to 56.79) for occlusal caries at the 1/3 dentin detection level; ungraded.
4 findings from 1 review
DOR 16.6 [4.85, 56.79]
2 studies
GRADE not reported
Specificity 0.88 [0.83, 0.92]
2 studies
GRADE not reported
Sensitivity 0.69 [0.51, 0.82]
2 studies
GRADE not reported
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AUC 0.89
2 studies
GRADE not reported
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, phosphor-plate digital bitewing radiography had a summary ROC AUC of 0.92 for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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White spot lesions (WSLs), tooth level · Adults undergoing orthodontic treatment
A single study reported a lower risk of white spot lesions (tooth level) with aligners versus fixed appliances in adults at 3 months (RR 0.72, 95% CI 0.60 to 0.86; ungraded).
1 finding from 1 review
RR 0.72 [0.60, 0.86]
1 study
GRADE not reported
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, the crude HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 2.27 (95% CI 1.50 to 3.43; 1 study, I2 not applicable (single study)); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (F-speed) pooled specificity was 0.97 (95% CI 0.71 to 0.998) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (D-speed) pooled specificity was 0.73 (95% CI 0.53 to 0.87) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled summary ROC AUC was 0.59 for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, laser fluorescence pen (2190) pooled sensitivity was 0.78 (95% CI 0.44 to 0.94) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
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Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence in Sudan was 57.8% (95% CI 36.0 to 79.7); certainty not graded.
1 finding from 1 review
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 2.65, 95% CI 1.77 to 3.98; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
Hemoglobin (Hb) level at the end of the study · Preschool children (<6 years)
Hemoglobin levels were significantly lower in children with ECC than in caries-free children (mean difference -9.96, 95% CI -15.45 to -4.46); ungraded.
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth)
1 finding from 1 review
Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, sensor-based digital bitewing radiography had a pooled sensitivity of 0.96 (95% CI 0.91, 0.98) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review
Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement than fluoride varnish (MD 4.76, 95% CI 0.74 to 8.78; moderate certainty).
3 findings from 1 review
MD 4.76 [0.74, 8.78]
3 studies · 212 participants
Moderate
MD 3.65 [0.82, 6.48]
2 studies · 172 participants
GRADE not reported
MD 13.15 [3.98, 22.32]
1 study · 40 participants
GRADE not reported
Percentage of bleeding on probing (BOP) · Adults undergoing orthodontic treatment
No clear difference in bleeding on probing between aligners and fixed appliances in adults at 6-12 weeks (MD -0.26, 95% CI -0.77 to 0.26; very low certainty).
1 finding from 1 review