Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · people with symptomatic carotid stenosis

Carotid artery stenting leads to higher death or any stroke between randomisation and 30 days after… compared with endarterectomy (high certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or major or disabling stroke between randomisation and 30 days after treatment · people with symptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or major or disabling stroke between randomisation and 30 days… compared with endarterectomy (high certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke or myocardial infarction between randomisation and 30 days after treatment · people with symptomatic carotid stenosis

Carotid artery stenting leads to higher death or any stroke or myocardial infarction between randomisation… compared with endarterectomy (high certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or any stroke between randomisation and 30 days after treatment compared with endarterectomy (moderate certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or any stroke between randomisation and 30 days after… compared with endarterectomy (moderate certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or major or disabling stroke between randomisation and 30 days after treatment · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or major or disabling stroke between randomisation and 30 days… compared with endarterectomy (moderate certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke or myocardial infarction between randomisation and 30 days after treatment · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or any stroke or myocardial infarction between randomisation… compared with endarterectomy (moderate certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supplemental oxygen

Bronchopulmonary dysplasia at 28 days · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether CPAP changes bronchopulmonary dysplasia (oxygen dependency at 28 days) compared with supplemental oxygen (very low certainty).

1 finding from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Clinical cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral showed no clear difference in clinical cure (short term: 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

1 finding from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Mycological cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral probably leads to higher mycological cure (short term; 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Neonatal death (baby born alive at any gestation and dies within 28 days) · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids leads to lower neonatal death (infants born with signs of life who die within the… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Intervention not reported

Time to achieve full enteral feeding (days) · preterm infants with low birth weight

The intervention showed no clear difference in time to achieve full enteral feeding (days) (low certainty).

1 finding from 1 review