Cochrane · systematic review · CD004863
Early erythropoiesis‐stimulating agents in preterm or low birth weight infants
Ohlsson, A, Aher, SM · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 38.5%Moderate 4 · 30.8%High 4 · 30.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsComparison
Population: preterm infants with low birth weight
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Use of 1 or more red blood cell transfusions (low and high doses of EPO) | RR 0.79 [0.74, 0.85] | 19 studies · 1750 participants | Low |
Any neurodevelopmental impairment at 18 to 22 months' corrected age (in children examined) | RR 0.62 [0.48, 0.8] | 4 studies · 1130 participants | Low |
Bayley‐II MDI at 18 to 24 months Bayley Scales of Infant Development, Second Edition, yields 2 single age‐standardised composite scores (range 50 to 150): a Mental Development Index (MDI), which measures cognition through sensory perception, knowl... | 8.22 [6.52, 9.92] | 3 studies · 981 participants | Low |
Necrotising enterocolitis (stage not reported) | RR 0.69 [0.52, 0.91] | 15 studies · 2639 participants | Moderate |
Comparison
Population: preterm infants with low birth weight
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality during initial hospital stay (all causes of mortality) | RR 0.89 [0.68, 1.16] | 20 studies · 2212 participants | High |
Retinopathy of prematurity (stage ≥ 3) | RR 1.24 [0.81, 1.9] | 8 studies · 1283 participants | High |
Intraventricular haemorrhage (grades III and IV) | RR 0.6 [0.43, 0.85] | 8 studies · 1460 participants | Moderate |
Periventricular leukomalacia | RR 0.66 [0.48, 0.92] | 6 studies · 1469 participants | Moderate |
Survivors at discharge from hospital without severe IVH, PVL, ROP | RR 1 [0.93, 1.08] | 1 study · 443 participants | High |
Time to achieve full enteral feeding (days) | no estimate extracted | 1 study · 50 participants | Low |
Comparison
Population: preterm infants with low birth weight
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cerebral palsy at 18 to 24 months' corrected age | RR 0.72 [0.46, 1.13] | 6 studies · 1172 participants | High |
Comparison
Population: neonates born preterm with low birth weight
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BSID‐III composite cognitive scores at 18 to 22 months The Bayley‐III has 3 main sub tests: the Cognitive Scale, which includes items such as attention to familiar and unfamiliar objects, looking for a fallen object, and pretend play; the Language... | MD 7.8 [1.65, 13.95] | 1 study · 80 participants | Moderate |
WPPSI‐III FSIQ at 3.5 to 4 years of age Composite scores have a mean of 100 and a standard deviation of 15. Average is 90 to 109. | MD 11.9 [0.76, 23.04] | 1 study · 53 participants | Low |