Cochrane · systematic review · CD003481
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants
Ohlsson, A, Walia, R, Shah, SS · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
20
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 5%Low 9 · 45%Moderate 10 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsComparison
Population: preterm infants with patent ductus arteriosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to close a patent ductus arteriosus (after 3 doses) | RR 0.62 [0.44, 0.86] | 2 studies · 206 participants | Moderate |
Necrotising enterocolitis | RR 1.84 [0.87, 3.9] | 2 studies · 264 participants | Moderate |
Comparison
Population: preterm infants with patent ductus arteriosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to close a patent ductus arteriosus (PDA) (after single or 3 doses) | RR 1.07 [0.92, 1.24] | 24 studies · 1590 participants | Moderate |
Need for surgical closure of the PDA | RR 1.06 [0.81, 1.39] | 16 studies · 1275 participants | Moderate |
Duration of ventilator support (days) | no estimate extracted | 6 studies · 471 participants | Moderate |
Necrotising enterocolitis (any stage) | RR 0.68 [0.49, 0.94] | 18 studies · 1292 participants | Moderate |
Oliguria (urine output < 1 mL/kg/hour) | RR 0.28 [0.14, 0.54] | 6 studies · 576 participants | Moderate |
Serum/plasma creatinine levels (μmol/L) | no estimate extracted | 11 studies · 918 participants | Low |
Comparison
Population: preterm infants with patent ductus arteriosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to close a patent ductus arteriosus (PDA) (after 3 doses) | RR 0.96 [0.73, 1.27] | 8 studies · 272 participants | Low |
Need for surgical closure of the PDA | RR 0.93 [0.5, 1.74] | 4 studies · 174 participants | Low |
Necrotising enterocolitis (any stage) | RR 0.41 [0.23, 0.73] | 7 studies · 249 participants | Low |
Serum/plasma creatinine levels (µmol/L) | no estimate extracted | 5 studies · 190 participants | Very low |
Comparison
Population: preterm infants with patent ductus arteriosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to close a patent ductus arteriosus (after single or 3 doses) | RR 0.38 [0.26, 0.56] | 5 studies · 406 participants | Moderate |
Need for surgical closure of the ductus | RR 0.41 [0.41, 1.21] | 5 studies · 406 participants | Moderate |
Duration of ventilatory support | MD 0.54 | 2 studies · 134 participants | Low |
Serum/plasma creatinine levels (μmol/L) after treatment Normal values for male and female newborns 17.7 to 88.4 µmol/L | MD 22.47 | 2 studies · 170 participants | Low |
Oliguria (Urine output < 1 mL/kg/hour) | RR 0.14 [0.01, 2.66] | 4 studies · 304 participants | Low |
Comparison
Population: preterm infants with patent ductus arteriosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to close a patent ductus arteriosus after 3 doses of ibuprofen | RR 0.37 [0.22, 0.61] | 3 studies · 190 participants | Moderate |
Necrotising enterocolitis | RR 1 [0.4, 2.5] | 2 studies · 130 participants | Low |
Oliguria | RR 1.57 [0.44, 5.63] | 2 studies · 120 participants | Low |