Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

335 questions · 340 findings · 46 reviews · Pain, Palliative and Supportive Care

No studies found 66 · 19.4%GRADE not reported 16 · 4.7%Very low 102 · 30%Low 68 · 20%Moderate 59 · 17.4%High 29 · 8.5%

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Patient Global Impression of Change much or very much improved · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors may leads to higher patient Global Impression to be much or very much improved (PGIC) compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Depression, SD units: measured on CES‐D, HADS‐D, PHQ‐9. Higher scores indicate higher depressive symptom load. · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Depression, natural units: measured on CES‐D (from 0 to 60). Higher scores indicate higher depressive symptom load · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Participant preference · people with cancer pain
1 finding from 1 review

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes need for analgesic prescription for pain (supplemental analgesic… compared with infiltration of the incision (peri-incisional infiltration) (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Intravenous analgesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes need for analgesic prescription for pain (supplemental analgesic… compared with intravenous analgesia (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

Perioperative infraorbital nerve block may leads to lower need for analgesic prescription for pain (supplemental analgesic… compared with placebo (sham block) (low certainty).

1 finding from 1 review

Educational intervention vs usual care or attention control

Depression (at the end of the educational intervention) · patients with cancer‐related fatigue (adults)

It is very uncertain whether educational interventions changes depression (at the end of the educational intervention) compared with control (usual care or attention control) (very low certainty).

1 finding from 1 review